Plce1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Plce1
phospholipase C, epsilon 1
MGI:1921305

26 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Plce1^em1(IMPC)Mbp/Plce1^em1(IMPC)Mbp C57BL/6N-Plce1^em1(IMPC)Mbp/MbpMmucd	abnormal skin morphology	J:211773
	decreased lymphocyte cell number	J:211773
	increased heart weight	J:211773
	increased monocyte cell number	J:211773
	increased neutrophil cell number	J:211773
	prolonged QRS complex duration	J:211773
Plce1^tm1Avsm/Plce1^tm1Avsm B6.129S6-Plce1^tm1Avsm	abnormal calcium ion homeostasis	J:179540
Plce1^tm1Avsm/Plce1^tm1Avsm involves: 129S6/SvEvTac * C57BL/6	abnormal myocardial fiber physiology	J:117556
	decreased heart left ventricle muscle contractility	J:117556
	increased response of heart to induced stress	J:117556
Plce1^tm1Tkat/Plce1⁺ involves: 129/Sv * C57BL/6	decreased incidence of tumors by chemical induction	J:94952
Plce1^tm1Tkat/Plce1⁺ involves: 129/Sv * C57BL/6	decreased physiological sensitivity to xenobiotic	J:94952
Plce1^tm1Tkat/Plce1^tm1Tkat involves: 129/Sv * C57BL/6	abnormal aortic valve commissure morphology	J:97661
	abnormal semilunar valve development	J:97661
	aortic valve regurgitation	J:97661
	aortic valve stenosis	J:97661
	bicuspid aortic valve	J:97661
	decreased cardiac muscle contractility	J:97661
	decreased heart ventricle muscle contractility	J:97661
	decreased incidence of tumors by chemical induction	J:94952
	decreased physiological sensitivity to xenobiotic	J:94952
	dilated heart left ventricle	J:97661
	dilated heart right ventricle	J:97661
	enlarged heart	J:97661
	pulmonary valve regurgitation	J:97661
	thick aortic valve	J:97661
	thick pulmonary valve	J:97661
Plce1^tm2Avsm/Plce1^tm2Avsm A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf⁺ involves: 129S6/SvEvTac C57BL/6 * FVB/N	decreased response of heart to induced stress	J:197247

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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