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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rnd3
Rho family GTPase 3
MGI:1921444
41 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Rnd3Gt(IST12405G10)Tigm/Rnd3Gt(IST12405G10)Tigm
involves: C57BL/6N 		abnormal brain ependyma morphology J:197325
abnormal brain ventricular system morphology J:197325
abnormal cerebral aqueduct morphology J:197325
cerebral aqueductal stenosis J:197325
dilated third ventricle J:197325
domed cranium J:197325
enlarged lateral ventricles J:197325
hydrocephaly J:197325
Rnd3Gt(OST364657)Lex/Rnd3Gt(OST364657)Lex
involves: 129S5/SvEvBrd * C57BL/6J 		abnormal ear development J:172361
abnormal gait J:172361
abnormal hypaxial muscle morphology J:172361
abnormal limb posture J:172361
abnormal locomotor behavior J:172361
abnormal motor capabilities/coordination/movement J:172361
abnormal neuromuscular synapse morphology J:172361
abnormal pinna reflex J:172361
abnormal placing response J:172361
abnormal sciatic nerve morphology J:172361
abnormal spinal nerve morphology J:172361
abnormal tibialis anterior morphology J:172361
ataxia J:172361
behavioral developmental delay J:172361
convulsive seizures J:172361
decreased birth body size J:172361
decreased grip strength J:172361
decreased locomotor activity J:172361
decreased motor neuron number J:172361
delayed eyelid opening J:172361
delayed suckling reflex loss J:172361
impaired righting response J:172361
limb grasping J:172361
positive geotaxis J:172361
postnatal growth retardation J:172361
postnatal lethality, incomplete penetrance J:172361
premature death J:172361
short stride length J:172361
slow postnatal weight gain J:172361
weight loss J:172361
Rnd3tm1b(EUCOMM)Hmgu/Rnd3+
C57BL/6N-Rnd3tm1b(EUCOMM)Hmgu/H 		decreased grip strength J:211773
enlarged heart J:211773
increased large unstained cell number J:211773
polycystic kidney J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory