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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Atg7
autophagy related 7
MGI:1921494
121 phenotypes from 3 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Alpltm1(cre)Nagy/Alpl+
Atg7tm1Tchi/Atg7tm1Tchi
involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj 		abnormal acrosome assembly J:258511
abnormal acrosome morphology J:258511
abnormal cauda epididymis morphology J:258511
abnormal proacrosomal vesicle fusion J:258511
abnormal seminiferous tubule morphology J:258511
abnormal sperm nucleus morphology J:258511
abnormal spermiogenesis J:258511
decreased testis weight J:258511
globozoospermia J:258511
impaired acrosome reaction J:258511
impaired autophagy J:258511
impaired fertilization J:258511
increased male germ cell apoptosis J:258511
oligozoospermia J:258511
reduced male fertility J:258511
small testis J:258511
Atg7em1(IMPC)Ccpcz/Atg7+
C57BL/6N-Atg7em1(IMPC)Ccpcz/Ccpcz 		abnormal heart morphology J:211773
abnormal mammary gland morphology J:211773
abnormal retina morphology J:211773
abnormal skin morphology J:211773
enlarged heart J:211773
increased circulating serum albumin level J:211773
increased circulating total protein level J:211773
Atg7em1(IMPC)Ccpcz/Atg7em1(IMPC)Ccpcz
C57BL/6N-Atg7em1(IMPC)Ccpcz/Ccpcz 		abnormal embryo size J:211773
no spontaneous movement J:211773
preweaning lethality, incomplete penetrance J:211773
Atg7tm1.1Tchi/Atg7tm1.1Tchi
involves: C57BL/6 * CBA * FVB/N 		abnormal circulating amino acid level J:100199
abnormal intracellular organelle morphology J:100199
decreased body weight J:100199
neonatal lethality, complete penetrance J:100199
Atg7tm1Tchi/Atg7tm1Tchi
Aviltm2(cre)Fawa/Avil+
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal sensory neuron morphology J:160568
bradykinesia J:160568
curly tail J:160568
gliosis J:160568
increased neuron apoptosis J:160568
limb grasping J:160568
neurodegeneration J:160568
tremors J:160568
Atg7tm1Tchi/Atg7tm1Tchi
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj 		abnormal common lymphocyte progenitor cell morphology J:176843
abnormal hematopoietic stem cell morphology J:176843
abnormal hematopoietic stem cell physiology J:176843
abnormal leukocyte morphology J:176843
decreased B cell number J:176843
decreased bone marrow cell number J:176843
decreased common myeloid progenitor cell number J:176843
decreased hematopoietic stem cell number J:176843
decreased leukocyte cell number J:176843
decreased NK cell number J:176843
decreased T cell number J:176843
Atg7tm1Tchi/Atg7tm1Tchi
En1tm2(cre)Wrst/En1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		abnormal brain morphology J:192452
abnormal gait J:192452
abnormal locomotor behavior J:192452
abnormal neuron morphology J:192452
abnormal substantia nigra pars compacta morphology J:192452
astrocytosis J:192452
ataxia J:192452
decreased dopamine level J:192452
decreased survivor rate J:192452
neuron degeneration J:192452
premature death J:192452
Purkinje cell degeneration J:192452
tremors J:192452
weight loss J:192452
Atg7tm1Tchi/Atg7tm1Tchi
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj 		abnormal circulating chemokine level J:235399
abnormal kidney morphology J:235399
abnormal macrophage physiology J:235399
abnormal renal glomerulus morphology J:235399
decreased body weight J:235399
decreased circulating interleukin-10 level J:235399
glomerulonephritis J:235399
increased anti-double stranded DNA antibody level J:235399
increased anti-nuclear antigen antibody level J:235399
increased autoantibody level J:235399
increased blood urea nitrogen level J:235399
increased circulating creatinine level J:235399
increased circulating interleukin-1 beta level J:235399
increased circulating interleukin-6 level J:235399
increased circulating interleukin-12b level J:235399
increased IgG level J:235399
increased lymphocyte cell number J:235399
increased monocyte cell number J:235399
increased neutrophil cell number J:235399
increased susceptibility to systemic lupus erythematosus J:235399
increased urine protein level J:235399
Atg7tm1Tchi/Atg7tm1Tchi
Slc6a3tm1(cre)Xz/Slc6a3+
involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj 		abnormal neuron morphology J:192452
abnormal substantia nigra pars compacta morphology J:192452
decreased dopamine level J:192452
hyperactivity J:192452
neuron degeneration J:192452
Atg7tm1Tchi/Atg7tm1Tchi
Tg(CAG-cre/Esr1*)5Amc/0
involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj 		abnormal autophagosome formation J:258511
Atg7tm1Tchi/Atg7tm1Tchi
Tg(Camk2a-cre)T29-1Stl/0
involves: BALB/c * C57BL * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj 		abnormal dendritic spine morphology J:217829
abnormal response to social novelty J:217829
abnormal social investigation J:217829
impaired autophagy J:217829
Atg7tm1Tchi/Atg7tm1Tchi
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		abnormal amino acid level J:100199
abnormal circulating enzyme level J:100199
abnormal hepatocyte mitochondrial morphology J:100199
abnormal hepatocyte morphology J:100199, J:130839
abnormal liver morphology J:100199
abnormal liver physiology J:100199
decreased liver function J:130839
enlarged liver J:100199
impaired autophagy J:130839
increased circulating alanine transaminase level J:100199, J:130839
increased circulating alkaline phosphatase level J:100199, J:130839
increased circulating aspartate transaminase level J:100199, J:130839
increased hepatocyte proliferation J:130839
increased liver weight J:100199, J:130839
Atg7tm1Tchi/Atg7tm1Tchi
Tg(Nes-cre)1Kln/0
involves: C57BL/6NCrlj * CBA/JNCrlj * SJL 		abnormal endoplasmic reticulum morphology J:298097
normal cellular phenotype J:298097
normal nervous system phenotype J:298097
Atg7tm1Tchi/Atg7tm1Tchi
Tg(Nes-cre)1Wme/0
involves: C57BL/6 * CBA 		abnormal nervous system physiology J:130839
absent cerebral cortex pyramidal cells J:130839
absent hippocampus pyramidal cells J:130839
axon degeneration J:130839
impaired autophagy J:130839
increased neuron apoptosis J:130839
limb grasping J:130839
tremors J:130839
Atg7tm1Tchi/Atg7tm1Tchi
Tg(SLC18A3-cre)KMisa/0
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj 		abnormal motor neuron morphology J:193770
normal behavior/neurological phenotype J:193770
Atg7tm1Tchi/Atg7tm1Tchi
Tg(Tyr-cre)1Lru/Y
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2 		abnormal autophagy J:220623
abnormal coat/hair pigmentation J:220623
abnormal epidermal melanocyte morphology J:220623
abnormal epidermal pigmentation J:220623
abnormal melanocyte proliferation J:220623
abnormal melanosome morphology J:220623
decreased foot pigmentation J:220623
decreased tail pigmentation J:220623
dilated mitochondrion J:220623
early cellular replicative senescence J:220623
oxidative stress J:220623
Atg7tm1Tchi/Atg7tm1Tchi
Tg(Vil1-cre)1000Gum/0
involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj * SJL/J 		abnormal intestinal goblet cell morphology J:206181
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory