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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Atg7
autophagy related 7
MGI:1921494
53 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Apctm2.1Cip/Apc+
Atg7tm1Tchi/Atg7tm1Tchi
Tg(Vil1-cre/ERT2)23Syr/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2 		abnormal gut flora balance J:227287
abnormal immune system physiology J:227287
abnormal intestinal goblet cell morphology J:227287
abnormal intestine physiology J:227287
abnormal Paneth cell morphology J:227287
decreased intestinal adenoma incidence J:227287
increased CD8-positive, alpha-beta T cell number J:227287
increased CD103-positive CD11b-low dendritic cell number J:227287
increased interleukin-1 beta secretion J:227287
increased interleukin-10 secretion J:227287
increased regulatory T cell number J:227287
Atg7tm1Tchi/Atg7tm1Tchi
Cnot1tm1Tya/Cnot1tm1Tya
Tg(Ckmm-cre)5Khn/0
involves: C57BL/6NCrlj * CBA/JNCrlj * FVB 		cardiac muscle necrosis J:260012
decreased cardiac muscle contractility J:260012
postnatal lethality, complete penetrance J:260012
Atg7tm1Tchi/Atg7tm1Tchi
Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N 		decreased cardiac muscle contractility J:260012
premature death J:260012
Atg7tm1Tchi/Atg7tm1Tchi
Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cfTg(Myh6-cre/Esr1*)1Jmk
involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N 		decreased cardiac muscle contractility J:260012
Atg7tm1Tchi/Atg7tm1Tchi
Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb
Tg(Ckmm-cre)5Khn/0
involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB 		abnormal autophagosome formation J:260012
normal cardiovascular system phenotype J:260012
premature death J:260012
Atg7tm1Tchi/Atg7tm1Tchi
Lyz2tm1(cre)Ifo/Lyz2+
Tg(CAG-EGFP/Map1lc3b)53Nmz/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2 		abnormal circulating chemokine level J:235399
abnormal macrophage physiology J:235399
decreased circulating interleukin-10 level J:235399
increased circulating interleukin-1 beta level J:235399
increased circulating interleukin-6 level J:235399
Atg7tm1Tchi/Atg7tm1Tchi
Sqstm1tm1Keta/Sqstm1tm1Keta
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj 		abnormal hepatocyte morphology J:130839
decreased liver function J:130839
increased circulating alanine transaminase level J:130839
increased circulating alkaline phosphatase level J:130839
increased circulating aspartate transaminase level J:130839
Atg7tm1Tchi/Atg7tm1Tchi
Sqstm1tm1Keta/Sqstm1tm1Keta
Tg(Nes-cre)1Wme/0
involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj 		abnormal nervous system physiology J:130839
absent cerebral cortex pyramidal cells J:130839
absent hippocampus pyramidal cells J:130839
axon degeneration J:130839
decreased Purkinje cell number J:130839
increased neuron apoptosis J:130839
limb grasping J:130839
tremors J:130839
Atg7tm1Tchi/Atg7tm1Tchi
Tg(Nes-cre)1Kln/0
Wdr45btm1c(EUCOMM)Hmgu/Wdr45btm1c(EUCOMM)Hmgu
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL 		abnormal axon morphology J:298097
abnormal cerebellar granule cell morphology J:298097
abnormal endoplasmic reticulum morphology J:298097
abnormal Golgi apparatus morphology J:298097
cerebellum atrophy J:298097
impaired coordination J:298097
lethality during fetal growth through weaning, complete penetrance J:298097
postnatal growth retardation J:298097
prenatal lethality, incomplete penetrance J:298097
Purkinje cell degeneration J:298097
Atg7tm1Tchi/Atg7tm1Tchi
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Defa6-icre)1Rsb/0
involves: 129S6/SvEvTac * C57BL/6 * CBA 		small intestinal inflammation J:206084
Atg7tm1Tchi/Atg7tm1Tchi
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL 		abnormal autophagy J:206084
abnormal enterocyte physiology J:206084
ileum inflammation J:206084
intestinal inflammation J:206084
Tsc2tm1Djk/Tsc2+
Atg7tm1Tchi/Atg7tm1Tchi
Tg(Camk2a-cre)T29-1Stl/0
involves: 129S4/SvJae * BALB/c * C57BL * C57BL/6 * CBA/JNCrlj 		abnormal autophagy J:217829
abnormal dendritic spine morphology J:217829
abnormal response to social novelty J:217829
abnormal social investigation J:217829
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory