Mettl23 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mettl23
methyltransferase like 23
MGI:1921569

27 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mettl23^{em1(IMPC)Hmgu}/Mettl23^{em1(IMPC)Hmgu} C57BL/6NCrl-Mettl23^{em1(IMPC)Hmgu}/Ieg	abnormal behavior	J:211773
	abnormal head morphology	J:211773
	abnormal head size	J:211773
	abnormal optic disk morphology	J:211773
	abnormal retina morphology	J:211773
	decreased anxiety-related response	J:211773
	decreased locomotor activity	J:211773
	decreased startle reflex	J:211773
	decreased thigmotaxis	J:211773
	enlarged spleen	J:211773
	increased circulating unsaturated transferrin level	J:211773
	increased lean body mass	J:211773
	increased liver weight	J:211773
	increased mean platelet volume	J:211773
	increased spleen weight	J:211773
	increased total retina thickness	J:211773
	persistence of hyaloid vascular system	J:211773
Mettl23^em1Itwa/Mettl23⁺ C57BL/6J-Mettl23^em1Itwa/Itwa	abnormal rod electrophysiology	J:330971
	optic nerve atrophy	J:330971
	retina ganglion cell degeneration	J:330971
	thin retina ganglion layer	J:330971
	normal vision/eye phenotype	J:330971
Mettl23^em1Itwa/Mettl23^em1Itwa C57BL/6J-Mettl23^em1Itwa/Itwa	abnormal rod electrophysiology	J:330971
	optic nerve atrophy	J:330971
	retina ganglion cell degeneration	J:330971
	thin retina ganglion layer	J:330971
	vision/eye phenotype	J:330971
Mettl23^em1Ogu/Mettl23^em1Ogu involves: C57BL/6 * DBA/2	abnormal DNA methylation	J:254851
	decreased litter size	J:254851
	decreased survivor rate	J:254851
	postnatal lethality, incomplete penetrance	J:254851
Mettl23^em2Itwa/Mettl23⁺ C57BL/6J-Mettl23^em2Itwa/Itwa	abnormal rod electrophysiology	J:330971
	optic nerve atrophy	J:330971
	retina ganglion cell degeneration	J:330971
	thin retina ganglion layer	J:330971
	vision/eye phenotype	J:330971
Mettl23^em2Itwa/Mettl23^em2Itwa C57BL/6J-Mettl23^em2Itwa/Itwa	abnormal rod electrophysiology	J:330971
	optic nerve atrophy	J:330971
	retina ganglion cell degeneration	J:330971
	thin retina ganglion layer	J:330971
	vision/eye phenotype	J:330971

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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