Clec16a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Clec16a
C-type lectin domain family 16, member A
MGI:1921624

30 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Clec16a^curt/Clec16a^curt SWR/J-Clec16a^curt/GrsrJ	abnormal digit morphology	J:172931
	decreased body size	J:172931
	decreased body weight	J:172931
	impaired hearing	J:172931
	increased or absent threshold for auditory brainstem response	J:172931
	narrow eye opening	J:172931
	perinatal lethality, incomplete penetrance	J:172931
	premature death	J:172931
	preweaning lethality, incomplete penetrance	J:172931
	Purkinje cell degeneration	J:251104
	wavy tail	J:172931
Clec16a^em1(IMPC)J/Clec16a⁺ C57BL/6NJ-Clec16a^em1(IMPC)J/Mmjax	abnormal auditory brainstem response	J:211773
Clec16a^em1(IMPC)J/Clec16a^em1(IMPC)J C57BL/6NJ-Clec16a^em1(IMPC)J/Mmjax	abnormal body wall morphology	J:211773
	abnormal embryo size	J:211773
	preweaning lethality, complete penetrance	J:211773
Clec16a^tm1.1Hhak/Clec16a^tm1.1Hhak involves: C57BL/6 * SJL	no abnormal phenotype detected	J:214528
Clec16a^tm1.1Hhak/Clec16a^tm1.1Hhak Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 involves: 129S/SvEv * C57BL/6 * SJL	abnormal mitophagy	J:214528
	decreased oxygen consumption	J:214528
Clec16a^tm1.1Hhak/Clec16a^tm1.1Hhak Tg(Pdx1-cre)1Herr/0 involves: C57BL/6 * C57BL/6J * CBA/J * SJL	abnormal endoplasmic reticulum morphology	J:214528
	abnormal mitochondrial morphology	J:214528
	abnormal mitophagy	J:214528
	abnormal pancreatic alpha cell morphology	J:214528
	abnormal pancreatic beta cell morphology	J:214528
	abnormal pancreatic beta cell physiology	J:214528
	decreased insulin secretion	J:214528
	decreased oxygen consumption	J:214528
	disorganized mitochondrial cristae	J:214528
	normal endocrine/exocrine gland phenotype	J:214528
	hyperglycemia	J:214528
	impaired glucose tolerance	J:214528
	increased mitochondrial size	J:214528
Tg(CMV-GFP,-RNAi:Clec16a)KD3Kslr/0 NOD-Tg(CMV-GFP,-RNAi:Clec16a)KD3Kslr	increased physiological sensitivity to xenobiotic	J:285312

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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