Sost Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sost
sclerostin
MGI:1921749

33 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sost^{tm1(KOMP)Vlcg}/Sost^{tm1(KOMP)Vlcg} involves: C57BL/6NTac	abnormal bone mineralization	J:188586
	abnormal bone ossification	J:188586
	abnormal osteoblast morphology	J:188586
	abnormal trabecular bone morphology	J:188586
	increased bone mass	J:188586
	increased bone trabecula number	J:188586
	increased compact bone area	J:188586
	increased trabecular bone connectivity density	J:188586
	increased trabecular bone volume	J:188586
	normal skeleton phenotype	J:188586
Sost^{tm1(KOMP)Vlcg}/Sost^{tm1(KOMP)Vlcg} involves: C57BL/6NTac	abnormal compact bone morphology	J:167585
	abnormal trabecular bone morphology	J:167585
	decreased osteocyte apoptosis	J:167585
	increased bone mass	J:167585
	increased bone mineral density of femur	J:167585
	increased bone mineral density of lumbar vertebrae	J:167585
	increased compact bone area	J:167585
	increased compact bone thickness	J:167585
	increased trabecular bone thickness	J:167585
Sost^{tm1(KOMP)Vlcg}/Sost^{tm1(KOMP)Vlcg} involves: C57BL/6NTac	increased bone mineral density	J:200671
	increased bone volume	J:200671
	increased compact bone thickness	J:200671
Sost^{tm1(KOMP)Vlcg}/Sost^tm2.1Vlcg Tg(Nanog-cre)#Vlcg/0 involves: 129S6/SvEvTac * C57BL/6NTac	increased bone mineral density	J:200671
	increased bone volume	J:200671
	increased compact bone thickness	J:200671
Sost^tm1Dgen/Sost^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	abnormal bone ossification	J:179873
	decreased physiological sensitivity to xenobiotic	J:179873
	increased bone mass	J:179873
	increased bone mineral density	J:179873
	increased bone mineral density of lumbar vertebrae	J:179873
	increased compact bone thickness	J:179873
Sost^tm1Lex/Sost^tm1Lex involves: 129S5/SvEvBrd * C57BL/6	increased compact bone thickness	J:274615
Sost^tm1Lhe/Sost^tm1Lhe involves: C57BL/6J	abnormal bone remodeling	J:168665
	abnormal osteoblast morphology	J:168665
	abnormal osteoblast physiology	J:168665
	decreased osteoblast apoptosis	J:168665
	decreased osteocyte apoptosis	J:168665
	increased bone mass	J:168665
	increased bone mineral density	J:168665
	increased bone mineral density of femur	J:168665
	increased osteocyte number	J:168665
Sost^tm1Paz/Sost^tm1Paz involves: 129/Sv * Black Swiss	abnormal bone mineralization	J:213541
	abnormal bone ossification	J:150166
	abnormal osteoblast physiology	J:150166
	abnormal trabecular bone morphology	J:150166
	increased areal bone mineral density	J:150166
	increased body weight	J:150166
	increased bone mass	J:213541
	increased bone mineral content	J:213541
	increased bone mineral density	J:150166, J:213541
	increased bone mineral density of femur	J:150166
	increased bone stiffness	J:213541
	increased bone strength	J:150166, J:213541
	increased bone trabecula number	J:150166
	increased bone volume	J:213541
	increased compact bone area	J:150166
	increased compact bone mass	J:213541
	increased compact bone volume	J:150166
	increased trabecular bone mass	J:213541
	increased trabecular bone thickness	J:150166
	increased trabecular bone volume	J:150166
	long femur	J:150166
Sost^tm2.1Vlcg/Sost^tm2.1Vlcg involves: 129S6/SvEvTac * C57BL/6NTac	no abnormal phenotype detected	J:200671

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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