Cdkal1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdkal1
CDK5 regulatory subunit associated protein 1-like 1
MGI:1921765

23 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cdkal1^Gt(6062)Tgen/Cdkal1^Gt(6062)Tgen involves: C57BL/6 * C57BL/6J * CBA/JNCrj	abnormal glucose homeostasis	J:195460
	decreased abdominal fat pad weight	J:195460
	decreased body weight	J:195460
	decreased circulating glucose level	J:195460
	decreased circulating insulin level	J:195460
	decreased food intake	J:195460
	decreased insulin secretion	J:195460
	decreased liver triglyceride level	J:195460
	decreased skeletal muscle triglyceride level	J:195460
	decreased subcutaneous adipose tissue amount	J:195460
	increased circulating leptin level	J:195460
	increased liver triglyceride level	J:195460
	increased skeletal muscle triglyceride level	J:195460
Cdkal1^tm1.1Tomik/Cdkal1^tm1.1Tomik B6.Cg-Cdkal1^tm1.1Tomik	no abnormal phenotype detected	J:178248
Cdkal1^tm1.1Tomik/Cdkal1^tm1.1Tomik Tg(Ins2-cre)25Mgn/0 B6.Cg-Cdkal1^tm1.1Tomik Tg(Ins2-cre)25Mgn	abnormal insulin secretion	J:178248
	abnormal pancreatic beta cell physiology	J:178248
	abnormal pancreatic islet morphology	J:178248
	decreased insulin secretion	J:178248
	impaired glucose tolerance	J:178248
	increased circulating glucose level	J:178248
Cdkal1^tm1.2Tomik/Cdkal1^tm1.2Tomik B6.Cg-Cdkal1^tm1.2Tomik	abnormal cell physiology	J:178248
Cdkal1^{tm2b(EUCOMM)Wtsi}/Cdkal1^{tm2b(EUCOMM)Wtsi} C57BL/6N-Cdkal1^{tm2b(EUCOMM)Wtsi}/Ieg	abnormal lens morphology	J:211773
	increased exploration in new environment	J:211773
Tg(CAG-Cdkal1)#Tkyo/0 involves: C57BL/6NCrj	increased body weight	J:195460

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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