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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mlkl
mixed lineage kinase domain-like
MGI:1921818
11 phenotypes from 7 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mlklem1(IMPC)Ccpcz/Mlklem1(IMPC)Ccpcz
C57BL/6NCrl-Mlklem1(IMPC)Ccpcz/Ccpcz 		abnormal skin morphology J:211773
abnormal spleen morphology J:211773
enlarged spleen J:211773
Mlklem1Jhan/Mlklem1Jhan
involves: C57BL/6 		abnormal macrophage physiology J:204622
decreased sensitivity to induced cell death J:204622
decreased susceptibility to injury J:204622
normal immune system phenotype J:204622
normal mortality/aging J:204622
Mlklm1Btlr/Mlkl+
C57BL/6J-Mlklm1Btlr 		decreased cell death J:225934
decreased inflammatory response J:225934
Mlklm1Btlr/Mlklm1Btlr
C57BL/6J-Mlklm1Btlr 		decreased cell death J:225934
decreased inflammatory response J:225934
Mlklm2Btlr/Mlkl+
C57BL/6J-Mlklm2Btlr 		decreased cell death J:234252
decreased inflammatory response J:234252
Mlklm2Btlr/Mlklm2Btlr
C57BL/6J-Mlklm2Btlr 		decreased cell death J:234252
decreased inflammatory response J:234252
Mlklm3Btlr/Mlkl+
C57BL/6J-Mlklm3Btlr 		decreased cell death J:234251
decreased inflammatory response J:234251
Mlklm3Btlr/Mlklm3Btlr
C57BL/6J-Mlklm3Btlr 		decreased cell death J:234251
decreased inflammatory response J:234251
MlklM4Btlr/MlklM4Btlr
C57BL/6J-MlklM4Btlr 		decreased apoptosis J:272831
Mlkltm1.2Wsa/Mlkltm1.2Wsa
involves: BALB/cJ * C57BL/6 		decreased sensitivity to induced cell death J:204620
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory