E2f8 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

E2f8
E2F transcription factor 8
MGI:1922038

24 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
E2f3^tm2.1Gle/E2f3^tm2.1Gle E2f7^tm1.1Gle/E2f7^tm1.1Gle E2f8^tm1.1Gle/E2f8^tm1.1Gle involves: 129S6/SvEvTac	normal embryo phenotype	J:183999
E2f7^tm1.1Gle/E2f7⁺ E2f8^tm1.1Gle/E2f8^tm1.1Gle involves: 129S6/SvEvTac * FVB/N	no abnormal phenotype detected	J:131292
E2f7^tm1.1Gle/E2f7^tm1.1Gle E2f8^tm1.1Gle/E2f8⁺ involves: 129S6/SvEvTac * FVB/N	decreased body size	J:131292
	premature death	J:131292
E2f7^tm1.1Gle/E2f7^tm1.1Gle E2f8^tm1.1Gle/E2f8^tm1.1Gle involves: 129S6/SvEvTac	abnormal embryo development	J:183999
	abnormal placenta development	J:183999
	abnormal placental labyrinth vasculature morphology	J:183999
	abnormal spongiotrophoblast cell morphology	J:183999
	abnormal trophoblast layer morphology	J:183999
	embryonic lethality during organogenesis, complete penetrance	J:183999
	fetal growth retardation	J:183999
	increased placenta apoptosis	J:183999
	small placenta	J:183999
E2f7^tm1.1Gle/E2f7^tm1.1Gle E2f8^tm1.1Gle/E2f8^tm1.1Gle involves: 129S6/SvEvTac * FVB/N	abnormal blood vessel morphology	J:131292
	abnormal vitelline vasculature morphology	J:131292
	decreased embryo size	J:131292
	embryonic lethality during organogenesis, complete penetrance	J:131292
	hemorrhage	J:131292
	increased embryonic tissue cell apoptosis	J:131292
E2f7^tm1Gle/E2f7^tm1Gle E2f8^tm1Gle/E2f8^tm1Gle involves: 129S6/SvEvTac * FVB/N	increased cellular sensitivity to alkylating agents	J:131292
E2f7^tm1Gle/E2f7^tm1Gle E2f8^tm1Gle/E2f8^tm1Gle Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S6/SvEvTac * C57BL/6 * SJL	abnormal embryonic tissue morphology	J:183999
	abnormal respiratory system morphology	J:183999
	normal embryo phenotype	J:183999
	neonatal lethality	J:183999
E2f7^tm1Gle/E2f7^tm1Gle E2f8^tm1Gle/E2f8^tm1Gle Prl2c2^tm1(cre)Gle/Prl2c2⁺ involves: 129S6/SvEvTac	no abnormal phenotype detected	J:183999
E2f7^tm1Gle/E2f7^tm1Gle E2f8^tm1Gle/E2f8^tm1Gle Prl3d1^tm1(cre)Gle/Prl3d1⁺ involves: 129S6/SvEvTac	no abnormal phenotype detected	J:183999
E2f7^tm1Gle/E2f7^tm1Gle E2f8^tm1Gle/E2f8^tm1Gle Tg(Cyp19a1-cre)5912Gle/0 involves: 129S6/SvEvTac * FVB/N	abnormal embryonic tissue morphology	J:183999
	abnormal placenta morphology	J:183999
	embryonic growth retardation	J:183999
	embryonic lethality during organogenesis, complete penetrance	J:183999
	hemorrhage	J:183999
E2f7^tm1Gle/E2f7^tm1Gle E2f8^tm1Gle/E2f8^tm1Gle Tg(Tpbpa-cre,-EGFP)5Jcc/0 involves: 129S6/SvEvTac	no abnormal phenotype detected	J:183999

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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