Manf Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Manf
mesencephalic astrocyte-derived neurotrophic factor
MGI:1922090

26 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Manf^{tm1a(KOMP)Wtsi}/Manf^{tm1a(KOMP)Wtsi} involves: C57BL/6 * C57BL/6N * ICR	abnormal fat pad morphology	J:211812
	abnormal glucose homeostasis	J:211812
	abnormal pancreatic beta cell differentiation	J:211812
	abnormal translation	J:211812
	decreased body size	J:211812
	decreased circulating insulin level	J:211812
	decreased pancreatic beta cell mass	J:211812
	decreased pancreatic beta cell number	J:211812
	decreased pancreatic islet number	J:211812
	fetal growth retardation	J:211812
	hyperglycemia	J:211812
	increased pancreas apoptosis	J:211812
	polydipsia	J:211812
	postnatal growth retardation	J:211812
	slow postnatal weight gain	J:211812
Manf^{tm1a(KOMP)Wtsi}/Manf^{tm1a(KOMP)Wtsi} involves: C57BL/6N	abnormal cortical intermediate zone morphology	J:255942
	abnormal cortical plate morphology	J:255942
	abnormal neurite morphology	J:255942
	abnormal neuronal migration	J:255942
	abnormal neuronal stem cell morphology	J:255942
	abnormal translation	J:255942
	increased cerebral cortex cell density	J:255942
	normal nervous system phenotype	J:255942
	thin cerebral cortex	J:255942
	thin cortical plate	J:255942
Manf^{tm1c(KOMP)Wtsi}/Manf^{tm1c(KOMP)Wtsi} involves: C57BL/6N * FVB/N	decreased circulating insulin level	J:211812
	hyperglycemia	J:211812
Manf^{tm1c(KOMP)Wtsi}/Manf^{tm1c(KOMP)Wtsi} Tg(Nes-cre)1Kln/0 involves: C57BL/6 * C57BL/6N * SJL	normal endocrine/exocrine gland phenotype	J:211812
	normal homeostasis/metabolism phenotype	J:211812

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24