Tmprss12 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tmprss12
transmembrane (C-terminal) protease, serine 12
MGI:1922252

23 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tmprss12^em1(IMPC)Mbp/Tmprss12^em1(IMPC)Mbp C57BL/6NCrl-Tmprss12^em1(IMPC)Mbp/MbpMmucd	abnormal eye morphology	J:211773
	male infertility	J:211773
Tmprss12^em1Huizh/Tmprss12^em1Huizh C57BL/6-Tmprss12^em1Huizh	abnormal double-strand DNA break repair	J:324488
	abnormal male meiosis	J:324488
	abnormal mitochondrial ATP synthesis coupled electron transport	J:324488
	abnormal mitochondrial crista morphology	J:324488
	abnormal sperm midpiece morphology	J:324488
	abnormal sperm mitochondrial sheath morphology	J:324488
	abnormal sperm physiology	J:324488
	abnormal spermatogenesis	J:324488
	abnormal X-Y chromosome synapsis during male meiosis	J:324488
	asthenozoospermia	J:324488
	decreased fertilization frequency	J:324488
	decreased male germ cell number	J:324488
	decreased sperm progressive motility	J:324488
	impaired acrosome reaction	J:324488
	impaired sperm capacitation	J:324488
	increased male germ cell apoptosis	J:324488
	male infertility	J:324488
	oligozoospermia	J:324488
	normal reproductive system phenotype	J:324488
Tmprss12^em4Osb/Tmprss12^em4Osb involves: C57BL/6NJcl * DBA/2NJcl	asthenozoospermia	J:293874
	impaired binding of sperm to zona pellucida	J:293874
	impaired fertilization	J:293874
	impaired sperm migration in female genital tract	J:293874
	male infertility	J:293874

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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