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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rspo2
R-spondin 2
MGI:1922667
68 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Rspo2ftls/Rspo2+
involves: FVB/N 		cleft secondary palate J:83881
decreased ovulation rate J:83881
delayed kidney development J:83881
ovary cyst J:83881
reduced female fertility J:83881
single kidney J:83881
Rspo2ftls/Rspo2ftls
involves: FVB/N 		abnormal forelimb morphology J:83881
abnormal hindlimb morphology J:83881
abnormal kidney development J:83881
abnormal phalanx morphology J:83881
absence of all nails J:83881
absent fibula J:83881
absent radius J:83881
cleft secondary palate J:83881
perinatal lethality, complete penetrance J:83881
short tibia J:83881
single kidney J:83881
Rspo2ftls/Rspo2ftls
Not Specified 		abnormal autopod morphology J:188812
abnormal autopod rotation J:188812
abnormal digit morphology J:188812
abnormal forelimb morphology J:188812
abnormal hindlimb morphology J:188812
abnormal limb morphology J:188812
absent fibula J:188812
absent radius J:188812
absent tibia J:188812
short hindlimb J:188812
Rspo2tm1Hoka/Rspo2tm1Hoka
involves: C57BL/6 * CBA 		abnormal apical ectodermal ridge morphology J:133600
abnormal autopod morphology J:133600
abnormal digit morphology J:133600
abnormal forelimb morphology J:133600
abnormal forelimb zeugopod morphology J:133600
abnormal hindlimb morphology J:133600
abnormal limb development J:133600
abnormal phalanx morphology J:133600
absent fibula J:133600
perinatal lethality, complete penetrance J:133600
Rspo2tm1Nuv/Rspo2+
involves: 129 * C57BL/6 		reduced female fertility J:126341
Rspo2tm1Nuv/Rspo2tm1Nuv
involves: 129 * C57BL/6 		abnormal apical ectodermal ridge morphology J:126341
abnormal bone ossification J:126341
abnormal digestive system development J:171482
abnormal limb development J:126341
abnormal lung vasculature morphology J:126341
abnormal mandibular angle morphology J:171482
abnormal maxillary shelf morphology J:171482
abnormal maxillary zygomatic process morphology J:171482
abnormal palatal shelf fusion at midline J:171482
abnormal phalanx morphology J:126341
abnormal pharyngeal arch mesenchyme morphology J:171482
abnormal tooth development J:171482
absence of all nails J:126341
absent kidney J:126341
absent mandibular coronoid process J:171482
brachyphalangia J:126341
cleft palate J:126341
cleft secondary palate J:171482
decreased tongue size J:171482
decreased tympanic ring size J:171482
delayed palatal shelf elevation J:171482
growth retardation of incisors J:171482
perinatal lethality, complete penetrance J:126341
pulmonary hypoplasia J:126341
short fibula J:126341
short mandible J:171482
short Meckel's cartilage J:171482
short metatarsal bones J:126341
small mandible J:171482
small mandibular condyloid process J:171482
small maxilla J:171482
syndactyly J:126341
Rspo2tm1Suda/Rspo2tm1Suda
B6.Cg-Rspo2tm1Suda 		abnormal autopod morphology J:146829
abnormal laryngeal cartilage morphology J:146829
abnormal lung morphology J:146829
abnormal maxilla morphology J:146829
abnormal nail morphology J:146829
abnormal pulmonary alveolus morphology J:146829
abnormal temporal bone squamous part morphology J:146829
abnormal tracheal cartilage morphology J:146829
abnormal zygomatic bone morphology J:146829
absent mandibular coronoid process J:146829
arytenoid and cricoid cartilage fusion J:146829
cleft secondary palate J:146829
cleft upper lip J:146829
cyanosis J:146829
decreased palatine bone horizontal plate size J:146829
hindlimb oligodactyly J:146829
lung hemorrhage J:146829
maxillary shelf hypoplasia J:146829
neonatal lethality, complete penetrance J:146829
palatal shelves fail to meet at midline J:146829
pulmonary hypoplasia J:146829
respiratory failure J:146829
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory