Nhej1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nhej1
non-homologous end joining factor 1
MGI:1922820

25 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cyren^{tm1.1(KOMP)Vlcg}/Cyren^{tm1.1(KOMP)Vlcg} Nhej1^tm1Fwa/Nhej1^tm1Fwa involves: 129S6/SvEvTac * C57BL/6NTac	decreased fetal size	J:265834
	increased neuron apoptosis	J:265834
	lethality throughout fetal growth and development, complete penetrance	J:265834
Ercc6l2^em1Mengf/Ercc6l2^em1Mengf Nhej1^em1Mengf/Nhej1^em1Mengf Not Specified	abnormal T cell receptor V(D)J recombination	J:311900
Nhej1^tm1.1Ics/Nhej1^tm1.1Ics Trp53^tm1Tyj/Trp53^tm1Tyj involves: 129S2/SvPas * C57BL/6	abnormal T cell receptor V(D)J recombination	J:194422
	decreased NK T cell number	J:194422
	decreased thymocyte apoptosis	J:194422
Nhej1^tm1Fwa/Nhej1^tm1Fwa Trp53^tm1Tyj/Trp53^tm1Tyj involves: 129	increased B cell derived lymphoma incidence	J:138774
	increased medulloblastoma incidence	J:138774
	increased T cell derived lymphoma incidence	J:138774
Nhej1^tm1Fwa/Nhej1^tm1Fwa Xrcc5^tm1Nus/Xrcc5^tm1Nus involves: 129S6/SvEvTac * C57BL/6	athymia	J:236776
	decreased body size	J:236776
	normal mortality/aging	J:236776
	small spleen	J:236776
Paxx^em1Spj/Paxx^em1Spj Nhej1^tm1Fwa/Nhej1^tm1Fwa involves: 129S6/SvEvTac * C57BL/6NTac	abnormal thymus involution	J:236776
	absent lymphocyte	J:236776
	athymia	J:236776
	chromosomal instability	J:236776
	decreased birth body size	J:236776
	decreased body size	J:236776
	decreased body weight	J:236776
	decreased embryo size	J:236776
	decreased fetal size	J:236776
	decreased fetal weight	J:236776
	decreased spleen weight	J:236776
	decreased splenocyte number	J:236776
	increased neural tube apoptosis	J:236776
	lethality throughout fetal growth and development, incomplete penetrance	J:236776
	postnatal lethality, incomplete penetrance	J:236776
	small spleen	J:236776

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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