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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Smurf1
SMAD specific E3 ubiquitin protein ligase 1
MGI:1923038
16 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Smurf1tm1Wran/Smurf1+
Smurf2tm1Wran/Smurf2tm1Wran
involves: 129S1/Sv * 129X1/SvJ * ICR 		abnormal neural tube closure J:148693
abnormal neural tube morphology J:148693
abnormal notochord morphology J:148693
abnormal orientation of cochlear hair cell stereociliary bundles J:148693
abnormal orientation of outer hair cell stereociliary bundles J:148693
abnormal rostral-caudal body axis extension J:148693
curly tail J:148693
exencephaly J:148693
perinatal lethality, incomplete penetrance J:148693
spina bifida J:148693
Smurf1tm1Wran/Smurf1tm1Wran
Smurf2tm1Wran/Smurf2+
involves: 129S1/Sv * 129X1/SvJ * ICR 		abnormal notochord morphology J:148693
abnormal orientation of cochlear hair cell stereociliary bundles J:148693
abnormal orientation of outer hair cell stereociliary bundles J:148693
curly tail J:148693
exencephaly J:148693
perinatal lethality, incomplete penetrance J:148693
spina bifida J:148693
Smurf1tm1Wran/Smurf1tm1Wran
Smurf2tm1Wran/Smurf2tm1Wran
involves: 129S1/Sv * 129X1/SvJ * ICR 		abnormal embryonic neuroepithelium morphology J:148693
abnormal gastrulation J:148693
abnormal gastrulation movements J:148693
embryonic lethality during organogenesis, complete penetrance J:148693
enlarged floor plate J:148693
open neural tube J:148693
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory