Cyrib Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cyrib
CYFIP related Rac1 interactor B
MGI:1923520

22 phenotypes from 4 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cyrib^m1Ivdi/Cyrib^m1Ivdi involves: 129S1/Sv * 129X1/SvJ * DBA/2J	abnormal cecum morphology	J:282597
	abnormal large intestine goblet cell morphology	J:282597
	abnormal spleen morphology	J:282597
	abnormal spleen white pulp morphology	J:282597
	increased circulating interleukin-6 level	J:282597
	increased circulating interleukin-10 level	J:282597
	increased circulating tumor necrosis factor level	J:282597
	increased neutrophil cell number	J:282597
	increased susceptibility to bacterial infection induced morbidity/mortality	J:282597
	intestinal edema	J:282597
	liver abscess	J:282597
	pulmonary parenchymal consolidation	J:282597
Cyrib^{tm1b(KOMP)Wtsi}/Cyrib⁺ C57BL/6N-Cyrib^{tm1b(KOMP)Wtsi}/Tcp	abnormal retina morphology	J:211773
	decreased circulating sodium level	J:211773
	decreased exploration in new environment	J:211773
Cyrib^{tm1b(KOMP)Wtsi}/Cyrib^{tm1b(KOMP)Wtsi} C57BL/6N-Cyrib^{tm1b(KOMP)Wtsi}/Tcp	abnormal retina morphology	J:211773
	edema	J:211773
	male infertility	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Cyrib^{tm1c(KOMP)Wtsi}/Cyrib^{tm1d(KOMP)Wtsi} Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * 129S4/SvJaeSor * BcA17/Skmn * C57BL/6N	abnormal actin cytoskeleton morphology	J:282597
	abnormal circulating chemokine level	J:282597
	abnormal neutrophil physiology	J:282597
	increased circulating CXCL10 level	J:282597
	increased circulating interleukin-6 level	J:282597
	increased circulating interleukin-10 level	J:282597
	increased circulating tumor necrosis factor level	J:282597
	increased susceptibility to bacterial infection induced morbidity/mortality	J:282597
	pulmonary parenchymal consolidation	J:282597

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24