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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tbx18
T-box18
MGI:1923615
49 phenotypes from 11 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hprt1tm3(CAG-Tbx18,-Venus)Akis/Y
Tbx18tm4(cre)Akis/Tbx18+
involves: 129S1/SvImJ * NMRI 		normal cardiovascular system phenotype J:210076
postnatal lethality, complete penetrance J:210076
Hprt1tm4(CAG-Tbx18*,-Venus)Akis/Y
Tbx18tm4(cre)Akis/Tbx18+
involves: 129S1/SvImJ * NMRI 		abnormal pericardium morphology J:210076
abnormal sinus venosus morphology J:210076
normal cardiovascular system phenotype J:210076
decreased fetal cardiomyocyte proliferation J:210076
heart hypoplasia J:210076
lethality throughout fetal growth and development, complete penetrance J:210076
thin ventricle myocardium compact layer J:210076
Tbx18tm1.1Akis/Tbx18tm1.1Akis
involves: 129S1/SvImJ * NMRI 		abnormal dorsal-ventral polarity of the somites J:90513
abnormal lumbar vertebrae morphology J:90513
abnormal rib morphology J:90513
abnormal spinal nerve morphology J:90513
abnormal thoracic vertebrae morphology J:90513
abnormal vertebrae development J:90513
abnormal vertebrae morphology J:90513
abnormal vertebral arch morphology J:90513
decreased birth body size J:90513
fused dorsal root ganglion J:90513
fusion of atlas and occipital bones J:90513
neonatal lethality, complete penetrance J:90513
rib fusion J:90513
small intervertebral disk J:90513
Tbx18tm1.1Mwmy/Tbx18tm1.1Mwmy
involves: 129 * C57BL/6J 		abnormal axial skeleton morphology J:203805
abnormal cardiovascular development J:203805
abnormal chest morphology J:203805
abnormal coronary vessel morphology J:203805
abnormal epicardium morphology J:203805
abnormal kidney morphology J:203805
abnormal myocardium compact layer morphology J:203805
abnormal rib morphology J:203805
abnormal ureter morphology J:203805
absent intervertebral disk J:203805
decreased body length J:203805
neonatal lethality, complete penetrance J:203805
respiratory distress J:203805
rib fusion J:203805
small intervertebral disk J:203805
Tbx18tm1Akis/Tbx18tm1Akis
involves: 129S1/SvImJ 		abnormal common cardinal vein morphology J:122633
abnormal heart morphology J:122633
abnormal vein morphology J:122633
Tbx18tm1Akis/Tbx18tm1Akis
involves: 129S1/SvImJ * NMRI 		abnormal dorsal-ventral polarity of the somites J:90513
abnormal lumbar vertebrae morphology J:90513
abnormal rib morphology J:90513
abnormal spinal nerve morphology J:90513
abnormal thoracic vertebrae morphology J:90513
abnormal vertebrae development J:90513
abnormal vertebrae morphology J:90513
abnormal vertebral arch morphology J:90513
decreased birth body size J:90513
fused dorsal root ganglion J:90513
fusion of atlas and occipital bones J:90513
neonatal lethality, complete penetrance J:90513
rib fusion J:90513
small intervertebral disk J:90513
Tbx18tm1Akis/Tbx18tm4(cre)Akis
involves: 129S1/SvImJ 		normal cardiovascular system phenotype J:210076
Tbx18tm1Sev/Tbx18tm1.1Sev
involves: 129S4/SvJaeSor 		abnormal skeleton morphology J:196480
decreased body length J:196480
normal integument phenotype J:196480
perinatal lethality J:196480
respiratory distress J:196480
Tbx18tm2Akis/Tbx18tm2Akis
involves: NMRI 		abnormal pleuropericardial membrane morphology J:192889
Tg(Dll1-Tbx18)2Akis/0
involves: FVB 		abnormal skeleton morphology J:90513
abnormal vertebrae morphology J:90513
abnormal vertebral pedicle morphology J:90513
thin ribs J:90513
Tg(Dll1-Tbx18)2Akis/Tg(Dll1-Tbx18)2Akis
involves: FVB 		abnormal vertebrae morphology J:90513
abnormal vertebral pedicle morphology J:90513
thin ribs J:90513
Tg(Dll1-Tbx18)20Akis/0
involves: FVB 		abnormal skeleton morphology J:90513
abnormal vertebrae morphology J:90513
abnormal vertebral pedicle morphology J:90513
thin ribs J:90513
Tg(Dll1-Tbx18)20Akis/Tg(Dll1-Tbx18)20Akis
involves: FVB 		abnormal dorsal-ventral polarity of the somites J:90513
abnormal spinal nerve morphology J:90513
abnormal thoracic cage shape J:90513
abnormal vertebrae morphology J:90513
abnormal vertebral pedicle morphology J:90513
absent proximal rib J:90513
decreased embryo size J:90513
lordosis J:90513
small thoracic cage J:90513
Tg(Adipoq-cre)1Evdr/0
involves: FVB/NJ 		decreased fasting circulating glucose level J:249843
improved glucose tolerance J:249843
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory