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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Plekha5
pleckstrin homology domain containing, family A member 5
MGI:1923802
51 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Aldh1a1tm1Gdu/Aldh1a1tm1Gdu
Aldh1a2tm1.1Mbp/Aldh1a2tm1.2Mbp
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: 129 * C57BL/6 * SJL 		abnormal spermatogenesis J:324715
azoospermia J:324715
decreased Sertoli cell number J:324715
male infertility J:324715
Artm1Chc/Y
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: 129S/SvEv * C57BL/6 * SJL 		abnormal meiosis J:118270
abnormal seminiferous tubule morphology J:89886, J:118270
abnormal spermatogenesis J:89886
arrest of male meiosis J:89886, J:118270
azoospermia J:89886, J:118270
decreased circulating testosterone level J:89886, J:118270
decreased male germ cell number J:89886
decreased testis weight J:89886
increased circulating follicle stimulating hormone level J:89886
increased circulating luteinizing hormone level J:89886
male infertility J:89886, J:118270
small testis J:118270
Artm1Jdz/Y
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: 129X1/SvJ * C57BL/6 * SJL 		abnormal Leydig cell morphology J:157337
arrest of spermatogenesis J:157337
decreased testis weight J:157337
normal growth/size/body region phenotype J:157337
Leydig cell hypertrophy J:157337
male infertility J:157337
small seminiferous tubules J:157337
Artm1Jdz/Y
Plekha5Tg(AMH-cre)1Flor/Plekha5+
Tg(Abpa-cre)1Cmal/0
involves: 129X1/SvJ * C57BL/6 * DBA/2 * SJL 		decreased testis weight J:157337
Artm1Jdz/Y
Plekha5Tg(AMH-cre)1Flor/Plekha5Tg(AMH-cre)1Flor
involves: 129X1/SvJ * C57BL/6 * SJL 		arrest of spermatogenesis J:157337
decreased testis weight J:157337
small seminiferous tubules J:157337
Artm1Verh/Y
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 		abnormal Leydig cell morphology J:100799
abnormal spermatid morphology J:88169
abnormal spermatocyte morphology J:88169
arrest of male meiosis J:88169
arrest of spermatogenesis J:88169
azoospermia J:88169
decreased epididymis weight J:88169
decreased Leydig cell number J:100799
decreased male germ cell number J:88169
decreased testis weight J:88169, J:100799
normal growth/size/body region phenotype J:88169
increased circulating follicle stimulating hormone level J:88169
increased male germ cell apoptosis J:88169
small seminiferous tubules J:88169
small testis J:88169
Cyp26b1tm1Ptk/Cyp26b1tm1Ptk
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal male meiosis J:154048
abnormal seminiferous tubule morphology J:154048
abnormal spermatogenesis J:154048
decreased male germ cell number J:154048
increased Leydig cell number J:154048
small seminiferous tubules J:154048
small testis J:154048
Ddb1tm1Spg/Ddb1tm1Spg
Plekha5Tg(AMH-cre)1Flor/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal seminiferous tubule morphology J:291677
abnormal testis cord formation J:291677
decreased Sertoli cell number J:291677
ectopic Sertoli cells J:291677
enlarged seminiferous tubules J:291677
oligozoospermia J:291677
small testis J:291677
Dicer1tm1Bdh/Dicer1tm1Bdh
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: 129/Sv * C57BL/6 * SJL 		abnormal male germ cell morphology J:145178
abnormal seminiferous tubule epithelium morphology J:145178
abnormal Sertoli cell morphology J:145178
abnormal spermatid morphology J:145178
abnormal spermatogenesis J:145178
azoospermia J:145178
decreased male germ cell number J:145178
decreased testis weight J:145178
ectopic Sertoli cells J:145178
increased Leydig cell number J:145178
increased male germ cell apoptosis J:145178
increased Sertoli cell proliferation J:145178
male infertility J:145178
normal reproductive system phenotype J:145178
seminiferous tubule degeneration J:145178
small seminiferous tubules J:145178
small testis J:145178
testis degeneration J:145178
Gja1tm1Kwi/Gja1tm1Kwi
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal Sertoli cell morphology J:122838
abnormal spermatid morphology J:122838
abnormal spermatogonia morphology J:122838
arrest of spermatogenesis J:122838
azoospermia J:122838
decreased male germ cell number J:122838
decreased testis weight J:122838
increased Leydig cell number J:122838
increased Sertoli cell number J:122838
male infertility J:122838
normal reproductive system phenotype J:122838
small seminiferous tubules J:122838
small testis J:122838
Klf4tm1Khk/Klf4tm1Khk
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: C57BL/6 * SJL 		abnormal seminiferous tubule epithelium morphology J:132612
abnormal seminiferous tubule size J:132612
abnormal Sertoli cell development J:132612
abnormal testes secretion J:132612
decreased circulating testosterone level J:132612
normal reproductive system phenotype J:132612
Mex3btm1.1Mbld/Mex3btm1.1Mbld
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: C57BL/6 * SJL 		abnormal seminiferous tubule morphology J:213588
abnormal Sertoli cell barrier function J:213588
normal growth/size/body region phenotype J:213588
increased anti-sperm antibody level J:213588
increased Sertoli cell number J:213588
normal mortality/aging J:213588
reduced male fertility J:213588
Pex5tm1Pec/Pex5tm1Pec
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: 129S1/Sv * 129X1/SvJ 		abnormal seminiferous tubule morphology J:108368
abnormal testis morphology J:108368
decreased testis weight J:108368
male infertility J:108368
seminiferous tubule degeneration J:108368
Plekha5Tg(AMH-cre)1Flor/Plekha5+
Wt1tm1Jae/Wt1tm2Vih
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL 		abnormal Leydig cell morphology J:111787
abnormal male reproductive system morphology J:111787
abnormal secondary sex determination J:111787
abnormal seminiferous tubule morphology J:111787
abnormal Sertoli cell development J:111787
abnormal testis morphology J:111787
male infertility J:111787
small testis J:111787
Ptpn11tm1Gsf/Ptpn11tm1Gsf
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal seminiferous tubule epithelium morphology J:250152
abnormal Sertoli cell barrier function J:250152
abnormal Sertoli cell barrier morphology J:250152
abnormal spermatocyte morphology J:250152
abnormal spermatogonia morphology J:250152
arrest of spermatogenesis J:250152
azoospermia J:250152
decreased male germ cell number J:250152
decreased testis weight J:250152
increased Leydig cell number J:250152
increased male germ cell apoptosis J:250152
male infertility J:250152
seminiferous tubule degeneration J:250152
small seminiferous tubules J:250152
Trim28tm1.1Ipc/Trim28tm1.1Ipc
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal spermatid morphology J:170392
abnormal spermiation J:170392
decreased litter size J:170392
decreased male germ cell number J:170392
decreased testis weight J:170392
oligozoospermia J:170392
reduced male fertility J:170392
normal reproductive system phenotype J:170392
testis degeneration J:170392
Trim28tm1Fca/Trim28tm1.1Ipc
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: 129S2/SvPas * C57BL/6 * SJL 		normal reproductive system phenotype J:170392
Tsc22d3tm1.1Hum/Y
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: 129S1/SvImJ * C57BL/6N * SJL/J 		normal reproductive system phenotype J:226675
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory