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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prss8
serine protease 8 (prostasin)
MGI:1923810
48 phenotypes from 9 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Prss8em1Bug/Prss8em1Bug
FVB/NJ-Prss8em1Bug 		curly vibrissae J:231031
delayed emergence of vibrissae J:231031
normal integument phenotype J:231031
kinked vibrissae J:231031
normal mortality/aging J:231031
sparse hair J:231031
Prss8fr/Prss8fr
involves: DBA * STOCK Tyrc-ch Oca2p Myo7ash1 		abnormal coat appearance J:92
abnormal hair growth J:92
abnormal hair medulla J:92
abnormal hair shaft morphology J:92
abnormal vibrissa morphology J:92
curly vibrissae J:92
disheveled coat J:92
rough coat J:92
short hair J:92
sparse hair J:92
Prss8fr/Prss8tm1.1Hum
involves: 129/Sv * FS/EiJ 		abnormal epidermis stratum corneum morphology J:159896
abnormal hair follicle morphology J:159896
curly vibrissae J:159896
decreased body weight J:159896
decreased hair follicle number J:159896
dry skin J:159896
sparse hair J:159896
underdeveloped hair follicles J:159896
Prss8Gt(IST10122F12)Tigm/Prss8Gt(IST10122F12)Tigm
involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N 		abnormal epidermis stratum corneum morphology J:188121
dehydration J:188121
impaired skin barrier function J:188121
postnatal lethality, complete penetrance J:188121
Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N 		decreased survivor rate J:214122
impaired skin barrier function J:214122
postnatal lethality, incomplete penetrance J:214122
Prss8tm1.1Bug/Prss8tm1.1Bug
involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N 		absent vibrissae J:214122
curly vibrissae J:214122
decreased body weight J:214122
delayed wound healing J:214122
impaired skin barrier function J:214122
kinked vibrissae J:214122
normal mortality/aging J:214122
short vibrissae J:214122
sparse hair J:214122
Prss8tm1.1Hum/Prss8tm1.2Hum
Tg(KRT14-cre)1Ipc/0
involves: 129/Sv * C57BL/6 * FVB/N * SJL 		abnormal corneocyte morphology J:100139
abnormal epidermal layer morphology J:100139
abnormal epidermis stratum corneum morphology J:100139
abnormal hair follicle development J:100139
abnormal hair follicle morphology J:100139
abnormal lipid level J:100139
decreased body weight J:100139
decreased hair follicle number J:100139
dehydration J:100139
impaired skin barrier function J:100139
orthokeratosis J:100139
postnatal lethality, complete penetrance J:100139
reddish skin J:100139
thymus medulla hypoplasia J:100139
weight loss J:100139
wrinkled skin J:100139
Prss8tm1.2Hum/Prss8tm1.2Hum
involves: 129 		no abnormal phenotype detected J:75109
Prss8tm1b(EUCOMM)Hmgu/Prss8+
C57BL/6N-Prss8tm1b(EUCOMM)Hmgu/J 		cataract J:211773
decreased mean corpuscular hemoglobin concentration J:211773
decreased thigmotaxis J:211773
Prss8tm1b(EUCOMM)Hmgu/Prss8tm1b(EUCOMM)Hmgu
C57BL/6N-Prss8tm1b(EUCOMM)Hmgu/J 		preweaning lethality, complete penetrance J:211773
Tg(KRT14-Prss8)1Hum/?
involves: C57BL/6 * DBA/2 		abnormal dermal layer morphology J:189278
abnormal stratum corneum lipid matrix formation J:189278
acanthosis J:189278
decreased body weight J:189278
excessive scratching J:189278
impaired skin barrier function J:189278
scaly skin J:189278
skin lesions J:189278
sparse hair J:189278
Tg(KRT14-Prss8)2Hum/?
involves: C57BL/6 * DBA/2 		abnormal dermal layer morphology J:189278
abnormal stratum corneum lipid matrix formation J:189278
acanthosis J:189278
decreased body weight J:189278
excessive scratching J:189278
impaired skin barrier function J:189278
postnatal lethality, incomplete penetrance J:189278
scaly skin J:189278
skin lesions J:189278
sparse hair J:189278
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory