Prss8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Prss8
serine protease 8 (prostasin)
MGI:1923810

48 phenotypes from 9 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Prss8^em1Bug/Prss8^em1Bug FVB/NJ-Prss8^em1Bug	curly vibrissae	J:231031
	delayed emergence of vibrissae	J:231031
	normal integument phenotype	J:231031
	kinked vibrissae	J:231031
	normal mortality/aging	J:231031
	sparse hair	J:231031
Prss8^fr/Prss8^fr involves: DBA * STOCK Tyr^c-ch Oca2^p Myo7a^sh1	abnormal coat appearance	J:92
	abnormal hair growth	J:92
	abnormal hair medulla	J:92
	abnormal hair shaft morphology	J:92
	abnormal vibrissa morphology	J:92
	curly vibrissae	J:92
	disheveled coat	J:92
	rough coat	J:92
	short hair	J:92
	sparse hair	J:92
Prss8^fr/Prss8^tm1.1Hum involves: 129/Sv * FS/EiJ	abnormal epidermis stratum corneum morphology	J:159896
	abnormal hair follicle morphology	J:159896
	curly vibrissae	J:159896
	decreased body weight	J:159896
	decreased hair follicle number	J:159896
	dry skin	J:159896
	sparse hair	J:159896
	underdeveloped hair follicles	J:159896
Prss8^{Gt(IST10122F12)Tigm}/Prss8^{Gt(IST10122F12)Tigm} involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N	abnormal epidermis stratum corneum morphology	J:188121
	dehydration	J:188121
	impaired skin barrier function	J:188121
	postnatal lethality, complete penetrance	J:188121
Prss8^tm1.1Bug/Prss8^{Gt(IST10122F12)Tigm} involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N	decreased survivor rate	J:214122
	impaired skin barrier function	J:214122
	postnatal lethality, incomplete penetrance	J:214122
Prss8^tm1.1Bug/Prss8^tm1.1Bug involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N	absent vibrissae	J:214122
	curly vibrissae	J:214122
	decreased body weight	J:214122
	delayed wound healing	J:214122
	impaired skin barrier function	J:214122
	kinked vibrissae	J:214122
	normal mortality/aging	J:214122
	short vibrissae	J:214122
	sparse hair	J:214122
Prss8^tm1.1Hum/Prss8^tm1.2Hum Tg(KRT14-cre)1Ipc/0 involves: 129/Sv * C57BL/6 * FVB/N * SJL	abnormal corneocyte morphology	J:100139
	abnormal epidermal layer morphology	J:100139
	abnormal epidermis stratum corneum morphology	J:100139
	abnormal hair follicle development	J:100139
	abnormal hair follicle morphology	J:100139
	abnormal lipid level	J:100139
	decreased body weight	J:100139
	decreased hair follicle number	J:100139
	dehydration	J:100139
	impaired skin barrier function	J:100139
	orthokeratosis	J:100139
	postnatal lethality, complete penetrance	J:100139
	reddish skin	J:100139
	thymus medulla hypoplasia	J:100139
	weight loss	J:100139
	wrinkled skin	J:100139
Prss8^tm1.2Hum/Prss8^tm1.2Hum involves: 129	no abnormal phenotype detected	J:75109
Prss8^{tm1b(EUCOMM)Hmgu}/Prss8⁺ C57BL/6N-Prss8^{tm1b(EUCOMM)Hmgu}/J	cataract	J:211773
	decreased mean corpuscular hemoglobin concentration	J:211773
	decreased thigmotaxis	J:211773
Prss8^{tm1b(EUCOMM)Hmgu}/Prss8^{tm1b(EUCOMM)Hmgu} C57BL/6N-Prss8^{tm1b(EUCOMM)Hmgu}/J	preweaning lethality, complete penetrance	J:211773
Tg(KRT14-Prss8)1Hum/? involves: C57BL/6 * DBA/2	abnormal dermal layer morphology	J:189278
	abnormal stratum corneum lipid matrix formation	J:189278
	acanthosis	J:189278
	decreased body weight	J:189278
	excessive scratching	J:189278
	impaired skin barrier function	J:189278
	scaly skin	J:189278
	skin lesions	J:189278
	sparse hair	J:189278
Tg(KRT14-Prss8)2Hum/? involves: C57BL/6 * DBA/2	abnormal dermal layer morphology	J:189278
	abnormal stratum corneum lipid matrix formation	J:189278
	acanthosis	J:189278
	decreased body weight	J:189278
	excessive scratching	J:189278
	impaired skin barrier function	J:189278
	postnatal lethality, incomplete penetrance	J:189278
	scaly skin	J:189278
	skin lesions	J:189278
	sparse hair	J:189278

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