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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tmem67
transmembrane protein 67
MGI:1923928
53 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tmem67b2b1163.1Clo/Tmem67b2b1163.1Clo
C57BL/6J-Tmem67b2b1163.1Clo 		atrioventricular septal defect J:175213
double outlet right ventricle J:175213
heart right ventricle hypoplasia J:175213
heterotaxia J:175213
interrupted aortic arch J:175213
polycystic kidney J:175213
Tmem67b2b1291.1Clo/Tmem67b2b1291.1Clo
C57BL/6J-Tmem67b2b1291.1Clo 		heterotaxia J:175213
polycystic kidney J:175213
right-sided stomach J:175213
situs inversus with levocardia J:175213
Tmem67em1(IMPC)J/Tmem67+
C57BL/6NJ-Tmem67em1(IMPC)J/Mmjax 		increased exploration in new environment J:211773
increased grip strength J:211773
Tmem67em1(IMPC)J/Tmem67em1(IMPC)J
C57BL/6NJ-Tmem67em1(IMPC)J/Mmjax 		preweaning lethality, complete penetrance J:211773
Tmem67tm1Dgen/Tmem67tm1Dgen
B6.129P2-Tmem67tm1Dgen 		abnormal basal ganglion morphology J:193837
abnormal brain ependyma motile cilium morphology J:193837
abnormal centrosome morphology J:193837
abnormal cilium morphology J:193837
abnormal corpus callosum morphology J:193837
abnormal dorsal-ventral axis patterning J:193837
abnormal embryonic neuroepithelium morphology J:193837
abnormal forebrain development J:193837
abnormal hepatobiliary system development J:193837
abnormal midbrain development J:193837
abnormal nervous system morphology J:193837
abnormal neural fold morphology J:193837
abnormal neural tube morphology J:193837
abnormal neural tube ventricular layer morphology J:193837
abnormal posterior cranial fossa morphology J:193837
abnormal renal tubule epithelial cell primary cilium morphology J:176174
abnormal roof plate morphology J:193837
abnormal tegmentum morphology J:193837
absent anterior commissure J:193837
absent embryonic cilia J:193837
normal cellular phenotype J:176174
cerebellum vermis hypoplasia J:193837
decreased forebrain size J:193837
decreased hindbrain size J:193837
dilated fourth ventricle J:193837
encephalomeningocele J:193837
enlarged hippocampus J:193837
exencephaly J:193837
incomplete rostral neuropore closure J:193837
increased forebrain size J:193837
kidney cyst J:176174, J:193837
normal limbs/digits/tail phenotype J:193837
mandible hypoplasia J:193837
meningocele J:193837
microcephaly J:193837
neonatal lethality, incomplete penetrance J:176174
perinatal lethality J:193837
postnatal growth retardation J:176174
postnatal lethality J:193837
postnatal lethality, incomplete penetrance J:176174
semilobar holoprosencephaly J:193837
small cerebellum J:193837
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory