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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Atg16l1
autophagy related 16 like 1
MGI:1924290
54 phenotypes from 8 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Atg16l1Gt(BC0122)Wtsi/Atg16l1Gt(BC0122)Wtsi
involves: 129P2/OlaHsd * C57BL/6 		abnormal Paneth cell morphology J:141419
impaired autophagy J:141419
normal reproductive system phenotype J:141419
Atg16l1Gt(XR0164)Wtsi/Atg16l1Gt(XR0164)Wtsi
involves: 129P2/OlaHsd * C57BL/6 		abnormal Paneth cell morphology J:141419
impaired autophagy J:141419
Atg16l1tm1.1Mvlc/Atg16l1tm1.1Mvlc
C57BL/6-Atg16l1tm1.1Mvlc 		abnormal macrophage physiology J:206931
normal digestive/alimentary phenotype J:206931
normal immune system phenotype J:206931
impaired autophagy J:206931
increased circulating interleukin-1 beta level J:206931
increased macrophage cytokine production J:206931
increased susceptibility to bacterial infection J:206931
Atg16l1tm1a(EUCOMM)Wtsi/Atg16l1+
C57BL/6N-Atg16l1tm1a(EUCOMM)Wtsi/Wtsi 		increased circulating serum albumin level J:175295
increased mean corpuscular hemoglobin J:175295
Atg16l1tm1a(EUCOMM)Wtsi/Atg16l1tm1a(EUCOMM)Wtsi
C57BL/6N-Atg16l1tm1a(EUCOMM)Wtsi/Wtsi 		abnormal eye muscle morphology J:239583
abnormal hepatic vein morphology J:239583
abnormal hypoglossal nerve topology J:239583
abnormal inferior vena cava valve morphology J:239583
abnormal intrathoracic topology of vagus nerve J:239583
abnormal thymus topology J:239583
abnormal vitelline vein topology J:239583
absent connection between subcutaneous lymph vessels and lymph sac J:239583
absent ductus venosus valve J:239583
absent hypoglossal nerve J:239583
absent segment of posterior cerebral artery J:239583
blood in lymph vessels J:239583
overriding aortic valve J:239583
perimembraneous ventricular septal defect J:239583
preweaning lethality, complete penetrance J:211773
subcutaneous edema J:239583
thoracoschisis J:239583
Atg16l1tm1a(EUCOMM)Wtsi/Atg16l1tm1a(EUCOMM)Wtsi
involves: C57BL/6N 		prenatal lethality J:221019
Atg16l1tm1Aki/Atg16l1tm1Aki
involves: 129/Sv * C57BL/6 		abnormal autophagosome formation J:141420
abnormal macrophage physiology J:141420
impaired autophagy J:141420
increased interleukin-1 beta secretion J:141420
increased interleukin-18 secretion J:141420
increased susceptibility to induced colitis J:141420
neonatal lethality, complete penetrance J:141420
Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi
Pgrtm2(cre)Lyd/Pgr+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N 		abnormal decidualization J:287978
decreased litter size J:287978
impaired embryo implantation J:287978
reduced female fertility J:287978
Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi
Tg(Defa6-icre)1Rsb/0
involves: C57BL/6 		abnormal intestine physiology J:340266
increased susceptibility to colitis induced morbidity/mortality J:340266
increased susceptibility to induced colitis J:340266
Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi
Tg(Itgax-cre)1-1Reiz/?
involves: C57BL/6 * C57BL/6N * CBA 		normal cellular phenotype J:221019
normal immune system phenotype J:221019
Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi
Tg(Vil1-cre)997Gum/?
involves: C57BL/6J * C57BL/6N * SJL 		abnormal autophagy J:221019
abnormal chemokine level J:221019
abnormal circulating interleukin level J:221019
abnormal cytokine level J:221019
abnormal Paneth cell morphology J:221019
cecum inflammation J:221019
decreased Paneth cell number J:221019
increased circulating interleukin-1 beta level J:221019
increased circulating interleukin-6 level J:221019
increased macrophage cell number J:221019
increased susceptibility to bacterial infection J:221019
Atg16l1tm1Kuv/Atg16l1tm1Kuv
Tg(Vil1-cre)997Gum/0
B6.Cg-Atg16l1tm1Kuv Tg(Vil1-cre)997Gum 		decreased body weight J:269933
increased enterocyte apoptosis J:269933
increased susceptibility to induced colitis J:269933
small intestinal inflammation J:269933
Atg16l1tm1Kuv/Atg16l1tm1Kuv
Tg(Vil1-cre)997Gum/0
involves: C57BL/6 * SJL 		abnormal autophagy J:206084
abnormal enterocyte morphology J:206084
abnormal enterocyte physiology J:206084
abnormal Paneth cell morphology J:206084
Atg16l1tm2.1Mvlc/Atg16l1tm2.1Mvlc
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 		impaired autophagy J:206931
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory