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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Kmt2e
lysine (K)-specific methyltransferase 2E
MGI:1924825
64 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Kmt2etm1.1Hjf/Kmt2e+
B6.129P2-Kmtetm1.1Hjf 		decreased thymocyte number J:145579
spleen hypoplasia J:145579
thymus hypoplasia J:145579
Kmt2etm1.1Hjf/Kmt2etm1.1Hjf
B6.129P2-Kmtetm1.1Hjf 		abnormal bone marrow cell morphology/development J:145579
abnormal lymphopoiesis J:145579
abnormal myeloblast morphology/development J:145579
decreased B cell number J:145579
decreased body size J:145579
decreased body weight J:145579
decreased common myeloid progenitor cell number J:145579
decreased double-negative T cell number J:145579
decreased double-positive T cell number J:145579
decreased erythrocyte cell number J:145579
decreased hematocrit J:145579
decreased hematopoietic stem cell number J:145579
decreased leukocyte cell number J:145579
decreased macrophage cell number J:145579
decreased pre-B cell number J:145579
decreased pro-B cell number J:145579
decreased T cell number J:145579
decreased thymocyte number J:145579
globozoospermia J:145579
normal immune system phenotype J:145579
increased mortality induced by gamma-irradiation J:145579
male infertility J:145579
neonatal lethality, incomplete penetrance J:145579
postnatal lethality, incomplete penetrance J:145579
reduced female fertility J:145579
small lymph nodes J:145579
small spleen J:145579
small thymus J:145579
spleen hypoplasia J:145579
thrombocytopenia J:145579
thymus hypoplasia J:145579
Kmt2etm1Apa/Kmt2etm1Apa
129S6/SvEvTac-Kmt2etm1Apa 		abnormal acrosome morphology J:181000
abnormal cauda epididymis morphology J:181000
abnormal definitive hematopoiesis J:145445
abnormal granulocyte differentiation J:145445
abnormal neutrophil differentiation J:145445
abnormal neutrophil physiology J:145445
abnormal sperm head morphology J:181000
abnormal sperm nucleus morphology J:181000
abnormal spermatogenesis J:181000
abnormal spermiogenesis J:181000
asthenozoospermia J:181000
blepharitis J:145445
decreased body weight J:145445
decreased hematocrit J:145445
decreased hemoglobin content J:145445
decreased sperm progressive motility J:181000
decreased total body fat amount J:145445
detached acrosome J:181000
dilated seminal vesicle J:145445
normal homeostasis/metabolism phenotype J:181000
impaired fertilization J:181000
impaired sperm penetration of zona pellucida J:181000
increased hemoglobin concentration distribution width J:145445
increased susceptibility to bacterial infection J:145445
lethality during fetal growth through weaning, incomplete penetrance J:145445
low mean erythrocyte cell number J:145445
male infertility J:145445, J:181000
normal reproductive system phenotype J:181000
Kmt2etm1Nik/Kmt2etm1Nik
B6.Cg-Kmtetm1Nik 		abnormal definitive hematopoiesis J:145449
abnormal hematopoietic stem cell morphology J:145449
decreased hematopoietic stem cell number J:145449
decreased NK cell number J:145449
decreased NK T cell number J:145449
normal hematopoietic system phenotype J:145449
increased hematopoietic stem cell number J:145449
increased neutrophil cell number J:145449
neonatal lethality, incomplete penetrance J:145449
postnatal growth retardation J:145449
postnatal lethality, complete penetrance J:145449
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory