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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ehmt1
euchromatic histone methyltransferase 1
MGI:1924933
83 phenotypes from 7 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ehmt1Tg(Tyr)2265COve/Ehmt1Tg(Tyr)2265COve
FVB/N-Ehmt1Tg(Tyr)2265COve 		embryonic lethality during organogenesis, complete penetrance J:175597
Ehmt1tm1.1Tara/Ehmt1tm1.1Tara
Myf5tm3(cre)Sor/Myf5+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 		decreased brown fat cell size J:207678
decreased brown fat lipid droplet number J:207678
decreased interscapular fat pad weight J:207678
Ehmt1tm1.1Tara/Ehmt1tm1.1Tara
Tg(Adipoq-cre)1Evdr/0
involves: 129P2/OlaHsd * FVB/NJ 		abnormal brown adipose tissue physiology J:207678
abnormal liver morphology J:207678
abnormal oxygen consumption J:207678
decreased body temperature J:207678
decreased fatty acid oxidation J:207678
impaired adaptive thermogenesis J:207678
impaired glucose tolerance J:207678
increased body weight J:207678
increased brown fat cell lipid droplet size J:207678
increased circulating free fatty acids level J:207678
increased circulating glucose level J:207678
increased circulating insulin level J:207678
increased epididymal fat pad weight J:207678
increased interscapular fat pad weight J:207678
increased liver triglyceride level J:207678
increased white fat cell lipid droplet size J:207678
insulin resistance J:207678
Ehmt1tm1.1Tara/Ehmt1tm1.1Tara
Tg(Camk2a-cre)2Gsc/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal liquid preference J:155739
abnormal motor coordination/balance J:155739
decreased anxiety-related response J:155739
decreased exploration in new environment J:155739
decreased locomotor activity J:155739
decreased vertical activity J:155739
impaired behavioral response to xenobiotic J:155739
impaired contextual conditioning behavior J:155739
impaired cued conditioning behavior J:155739
normal nervous system phenotype J:155739
obese J:155739
Ehmt1tm1.2Tara/Ehmt1+
Tg(CMV-cre)1Cgn/0
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 		decreased exploration in new environment J:155739
decreased locomotor activity J:155739
decreased vertical activity J:155739
Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju 		abnormal behavior J:211773
cornea opacity J:211773
decreased blood urea nitrogen level J:211773
decreased circulating creatinine level J:211773
decreased circulating serum albumin level J:211773
decreased exploration in new environment J:211773
decreased locomotor activity J:211773
increased anxiety-related response J:211773
increased grip strength J:211773
increased lean body mass J:211773
increased mean platelet volume J:211773
increased neutrophil cell number J:211773
increased thigmotaxis J:211773
Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Wtsi 		increased circulating cholesterol level J:211773
increased circulating LDL cholesterol level J:211773
Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1tm1b(EUCOMM)Hmgu
C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju 		preweaning lethality, complete penetrance J:211773
Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1tm1b(EUCOMM)Hmgu
C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Wtsi 		preweaning lethality, complete penetrance J:211773
Ehmt1tm1Bzhu/Ehmt1tm1Bzhu
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal epigenetic regulation of gene expression J:219788
abnormal metopic suture morphology J:219788
abnormal nasal bone morphology J:219788
abnormal suckling behavior J:219788
absent gastric milk in neonates J:219788
decreased birth body size J:219788
decreased embryo weight J:219788
decreased fetal weight J:219788
decreased survivor rate J:219788
delayed intramembranous bone ossification J:219788
malocclusion J:219788
postnatal growth retardation J:219788
postnatal lethality, incomplete penetrance J:219788
prenatal growth retardation J:219788
Ehmt1tm1Yshk/Ehmt1+
involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj 		abnormal associative learning J:192316
abnormal dendrite morphology J:192316
abnormal dendritic spine morphology J:192316
abnormal hippocampus pyramidal cell morphology J:192316
abnormal miniature excitatory postsynaptic currents J:192316
abnormal object recognition memory J:192316
abnormal response to novel object J:157021, J:192316
abnormal sensory capabilities/reflexes/nociception J:192316
abnormal social investigation J:157021
abnormal social/conspecific interaction behavior J:157021
decreased anxiety-related response J:157021
decreased exploration in new environment J:157021
decreased locomotor activity J:157021
decreased vertical activity J:157021
enhanced paired-pulse facilitation J:192316
impaired contextual conditioning behavior J:192316
impaired cued conditioning behavior J:192316
impaired synaptic plasticity J:192316
increased anxiety-related response J:157021
increased startle reflex J:192316
Ehmt1tm1Yshk/Ehmt1tm1Yshk
involves: C57BL/6NCrlj * CBA/JNCrlj 		embryonic growth retardation J:97244
embryonic lethality during organogenesis, complete penetrance J:97244
incomplete somite formation J:97244
open neural tube J:97244
Ehmt1tm2Yshk/Ehmt1tm2Yshk
Not Specified 		no abnormal phenotype detected J:204470
Ehmt1tm2Yshk/Ehmt1tm2Yshk
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd 		abnormal mitral valve cusp morphology J:204470
absent tricuspid valve cusps J:204470
atrioventricular septal defect J:204470
decreased atrioventricular cushion size J:204470
neonatal lethality, incomplete penetrance J:204470
premature death J:204470
Ehmt1tm2Yshk/Ehmt1tm2Yshk
Tg(Myh6-cre)2182Mds/0
involves: FVB/N 		no abnormal phenotype detected J:204470
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory