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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Orai1
ORAI calcium release-activated calcium modulator 1
MGI:1925542
14 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd79atm1(cre)Reth/Cd79a+
Orai1tm1Smua/Orai1tm1Smua
Orai3em1.1Treb/Orai3em1.1Treb
involves: BALB/c * C57BL/6J * C57BL/6N 		abnormal B cell activation J:345485
abnormal B cell physiology J:345485
abnormal calcium ion homeostasis J:345485
decreased B cell proliferation J:345485
normal immune system phenotype J:345485
Orai1tm1.1Hjm/Orai1tm1.1Hjm
Orai2tm1.1(KOMP)Vlcg/Orai2tm1.1(KOMP)Vlcg
Tg(Cd4-cre)1Cwi/0
B6.Cg-Tg(Cd4-cre)1Cwi Orai1tm1.1Hjm Orai2tm1.1(KOMP)Vlcg 		abnormal CD4-positive helper T cell morphology J:241365
abnormal T cell physiology J:241365
decreased germinal center B cell number J:241365
decreased IgG level J:241365
decreased regulatory T cell number J:241365
decreased single-positive T cell number J:241365
normal hematopoietic system phenotype J:241365
normal immune system phenotype J:241365
lymph node hyperplasia J:241365
spleen hyperplasia J:241365
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory