Rictor Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rictor
RPTOR independent companion of MTOR, complex 2
MGI:1926007

53 phenotypes from 8 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rictor^{Gt(RRR347)Byg}/Rictor^{Gt(RRR347)Byg} involves: 129P2/OlaHsd	abnormal placenta morphology	J:137592
	embryonic growth retardation	J:137592
	embryonic lethality during organogenesis, complete penetrance	J:137592
	thick placenta labyrinth	J:137592
Rictor^{Gt(RRR347)Byg}/Rictor^{Gt(RRR347)Byg} involves: 129P2/OlaHsd * C57BL/6J	embryonic lethality during organogenesis, complete penetrance	J:113443
Rictor^tm1.1Klg/Rictor^tm1.1Klg Tg(Mx1-cre)1Cgn/0 B6.Cg-Rictor^tm1.1Klg Tg(Mx1-cre)1Cgn	abnormal double-negative T cell morphology	J:189736
	decreased DN1 thymic pro-T cell number	J:189736
	decreased DN2 thymocyte number	J:189736
	decreased DN3 thymocyte number	J:189736
	decreased DN4 thymocyte number	J:189736
	decreased double-positive T cell number	J:189736
	decreased single-positive T cell number	J:189736
	decreased T cell proliferation	J:189736
	decreased thymus weight	J:189736
	normal hematopoietic system phenotype	J:189736
	normal immune system phenotype	J:189736
	increased double-negative T cell number	J:189736
	thymus hypoplasia	J:189736
Rictor^tm1.1Mgn/Rictor^tm1.1Mgn Tg(Ins2-cre)25Mgn/0 involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA	abnormal glucose homeostasis	J:170129
	abnormal pancreatic beta cell physiology	J:170129
	decreased insulin secretion	J:170129
	decreased pancreatic beta cell mass	J:170129
	decreased pancreatic beta cell proliferation	J:170129
	hyperglycemia	J:170129
	impaired glucose tolerance	J:170129
Rictor^tm1.1Mgn/Rictor^tm1.2Mgn Meox2^tm1(cre)Sor/Meox2⁺ involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL	lethality throughout fetal growth and development, incomplete penetrance	J:119564
Rictor^tm1.1Mnh/Rictor^tm1.1Mnh Tg(Fabp4-cre)1Rev/0 B6.Cg-Rictor^tm1.1Mnh Tg(Fabp4-cre)1Rev	decreased adiponectin level	J:150064
	enlarged pancreatic islets	J:150064
	improved glucose tolerance	J:150064
	increased body length	J:150064
	increased bone mineral content	J:150064
	increased circulating cholesterol level	J:150064
	increased circulating insulin level	J:150064
	increased circulating insulin-like growth factor I level	J:150064
	increased epididymal fat pad weight	J:150064
	increased heart weight	J:150064
	increased kidney weight	J:150064
	increased lean body mass	J:150064
	increased liver weight	J:150064
	increased pancreas weight	J:150064
	increased spleen weight	J:150064
	increased susceptibility to weight gain	J:150064
	insulin resistance	J:150064
	macrovesicular hepatic steatosis	J:150064
Rictor^tm1.2Mgn/Rictor^tm1.2Mgn involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL	abnormal placenta labyrinth morphology	J:119564
	abnormal placental labyrinth vasculature morphology	J:119564
	decreased cell proliferation	J:119564
	decreased embryo size	J:119564
	embryonic lethality during organogenesis, complete penetrance	J:119564
Rictor^tm1.2Mgn/Rictor^tm1.3Mgn involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL	abnormal placenta labyrinth morphology	J:119564
	abnormal placental labyrinth vasculature morphology	J:119564
	decreased embryo size	J:119564
	embryonic lethality during organogenesis, complete penetrance	J:119564
Rictor^tm1.3Mgn/Rictor^tm1.3Mgn involves: 129S6/SvEvTac * C57BL/6 * FVB/N	abnormal placenta labyrinth morphology	J:119564
	abnormal placental labyrinth vasculature morphology	J:119564
	decreased embryo size	J:119564
	embryonic lethality during organogenesis, complete penetrance	J:119564
Rictor^tm1Mgn/Rictor^tm1Mgn involves: 129S6/SvEvTac * C57BL/6	abnormal placenta labyrinth morphology	J:119564
	hydrops fetalis	J:119564
	lethality throughout fetal growth and development, complete penetrance	J:119564
	small placenta	J:119564
Rictor^tm1Rueg/Rictor^tm1Rueg Tg(ACTA1-cre)1Mll/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	increased body weight	J:143748
	normal mortality/aging	J:143748
	normal muscle phenotype	J:143748

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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