Rhot1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rhot1
ras homolog family member T1
MGI:1926078

30 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mnx1^tm4(cre)Tmj/Mnx1⁺ Rhot1^tm1.1Jmsu/Rhot1^tm1.2Jmsu involves: 129 * 129S1/Sv * C57BL/6 * SJL	no abnormal phenotype detected	J:216408
Rhot1^tm1.1Jmsu/Rhot1^tm1.1Jmsu Tg(Eno2-cre)39Jme/0 involves: 129 * C57BL/6 * C57BL/6J * SJL	abnormal brainstem morphology	J:216408
	abnormal motor capabilities/coordination/movement	J:216408
	abnormal tail movements	J:216408
	kyphosis	J:216408
	limb grasping	J:216408
	premature death	J:216408
	slow postnatal weight gain	J:216408
	spasticity	J:216408
Rhot1^tm1.2Jmsu/Rhot1^tm1.2Jmsu involves: 129 * 129S1/Sv * C57BL/6 * SJL	abnormal brainstem morphology	J:216408
	abnormal innervation	J:216408
	abnormal mitochondrial physiology	J:216408
	abnormal phrenic nerve morphology	J:216408
	normal cardiovascular system phenotype	J:216408
	cyanosis	J:216408
	decreased motor neuron number	J:216408
	neonatal lethality, complete penetrance	J:216408
	respiratory failure	J:216408
Rhot1^{tm1a(EUCOMM)Wtsi}/Rhot1^{tm1a(EUCOMM)Wtsi} B6Brd;B6Dnk;B6N-Tyr^c-Brd Rhot1^{tm1a(EUCOMM)Wtsi}/Wtsi	preweaning lethality, complete penetrance	J:211773
Rhot1^{tm1c(EUCOMM)Wtsi}/Rhot1^{tm1c(EUCOMM)Wtsi} Tg(Camk2a-cre)1Gsc/0 involves: C57BL/6Dnk * C57BL/6N * FVB/N	abnormal axonal transport	J:240500
	abnormal dendrite morphology	J:240500
	astrocytosis	J:240500
	decreased brain size	J:240500
	decreased neuron number	J:240500
	enlarged brain ventricles	J:240500
	neurodegeneration	J:240500
	small hippocampus	J:240500
	thin cerebral cortex	J:240500
Rhot1^{tm1d(EUCOMM)Wtsi}/Rhot1^{tm1d(EUCOMM)Wtsi} involves: C57BL/6Dnk * C57BL/6N	abnormal axonal transport	J:240500
	abnormal dendrite morphology	J:240500
	abnormal neurite morphology	J:240500
	abnormal neuron mitochondrial morphology	J:240500
	abnormal neuron morphology	J:240500
	cyanosis	J:240500
	neonatal lethality, complete penetrance	J:240500

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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