Atf6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Atf6
activating transcription factor 6
MGI:1926157

19 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Atf6^tm1.1Rjk/Atf6^tm1.1Rjk involves: C57BL/6 * C57BL/6J	abnormal electroretinogram waveform feature	J:231780
	abnormal photoreceptor inner segment morphology	J:231780
	abnormal photoreceptor outer segment morphology	J:231780
	abnormal retina pigment epithelium morphology	J:231780
	decreased b-wave amplitude	J:231780
	increased susceptibility to age-related retinal degeneration	J:231780
	retina outer nuclear layer degeneration	J:231780
Atf6^tm1.1Rjk/Atf6^tm1.1Rjk involves: C57BL/6 * FVB/N	abnormal cell physiology	J:124971
	abnormal endoplasmic reticulum physiology	J:124971
	decreased cell proliferation	J:124971
	hepatic steatosis	J:124971
	increased physiological sensitivity to xenobiotic	J:124971
	increased susceptibility to xenobiotic induced morbidity/mortality	J:124971
Atf6^tm1Hota/Atf6^tm1Hota Tg(Ins2-cre)25Mgn/0 B6.Cg-Atf6^tm1Hota Tg(Ins2-cre)25Mgn	decreased physiological sensitivity to xenobiotic	J:213542
	normal endocrine/exocrine gland phenotype	J:213542
	normal growth/size/body region phenotype	J:213542
	increased insulin sensitivity	J:213542
	increased pancreatic islet cell apoptosis	J:213542
Atf6^tm1Kamo/Atf6^tm1Kamo involves: 129S4/SvJae * C57BL/6J	increased sensitivity to induced cell death	J:145116

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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