Sp2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sp2
Sp2 transcription factor
MGI:1926162

28 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sp2^tm1.1Htg/Sp2⁺ Tg(Nes-cre)1Kln/0 involves: 129 * C57BL/6 * SJL	abnormal cerebral hemisphere morphology	J:194076
	abnormal rostral migratory stream morphology	J:194076
	decreased body size	J:194076
	decreased hippocampus volume	J:194076
	decreased neuronal precursor proliferation	J:194076
	postnatal growth retardation	J:194076
	small olfactory bulb	J:194076
Sp2^tm1.1Htg/Sp2^tm1.1Htg involves: 129	abnormal cell cycle	J:194076
Sp2^tm1.1Htg/Sp2^tm1.1Htg Emx1^tm1(cre)Krj/Emx1⁺ involves: 129S2/SvPas	abnormal cortical plate morphology	J:194076
	abnormal cortical ventricular zone morphology	J:194076
	abnormal embryonic/fetal subventricular zone morphology	J:194076
	abnormal neuron differentiation	J:194076
	prenatal lethality, incomplete penetrance	J:194076
Sp2^tm1.1Htg/Sp2^tm1.1Htg Tg(Nes-cre)1Kln/0 involves: 129 * C57BL/6 * SJL	abnormal cell cycle	J:194076
	abnormal cerebral hemisphere morphology	J:194076
	abnormal neuron differentiation	J:194076
	abnormal rostral migratory stream morphology	J:194076
	decreased body size	J:194076
	decreased hippocampus volume	J:194076
	decreased neuronal precursor proliferation	J:194076
	hydrocephaly	J:194076
	postnatal growth retardation	J:194076
	postnatal lethality, incomplete penetrance	J:194076
	premature death	J:194076
	small olfactory bulb	J:194076
Sp2^tm1.1Sus/Sp2^tm1.1Sus involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:158671
Sp2^tm1.2Sus/Sp2^tm1.2Sus involves: 129P2/OlaHsd * C57BL/6	abnormal embryo turning	J:158671
	absent fibroblast proliferation	J:158671
	decreased embryo size	J:158671
	embryonic growth retardation	J:158671
	embryonic lethality during organogenesis, complete penetrance	J:158671
	open neural tube	J:158671
Sp2^tm1Sus/Sp2^tm1Sus involves: 129P2/OlaHsd * C57BL/6	decreased fetal size	J:158671
	fetal growth retardation	J:158671
	hemorrhage	J:158671
	lethality throughout fetal growth and development, incomplete penetrance	J:158671
	postnatal lethality, complete penetrance	J:158671

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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