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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ltn1
listerin E3 ubiquitin protein ligase 1
MGI:1926163
35 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ltn1Gt(RRR322)Byg/Ltn1Gt(RRR322)Byg
involves: 129P2/OlaHsd 		embryonic lethality J:146493
Ltn1Gt(RRR322)Byg/Ltn1lister
involves: 129P2/OlaHsd * C57BL/6 		abnormal motor capabilities/coordination/movement J:146493
limb grasping J:146493
Ltn1lister/Ltn1lister
C57BL/6-Ltn1lister 		abnormal motor coordination/balance J:146493
abnormal muscle regeneration J:146493
abnormal neurite morphology J:146493
abnormal neuron morphology J:146493
abnormal neuron physiology J:146493
abnormal physical strength J:146493
astrocytosis J:146493
bradykinesia J:146493
decreased body size J:146493
decreased body weight J:146493
decreased grip strength J:146493
decreased skeletal muscle fiber size J:146493
impaired balance J:146493
impaired righting response J:146493
limb grasping J:146493
motor neuron degeneration J:146493
muscular atrophy J:146493
neuron degeneration J:146493
paralysis J:146493
paraparesis J:146493
slow postnatal weight gain J:146493
weaving J:146493
Ltn1tm1b(EUCOMM)Hmgu/Ltn1+
C57BL/6N-Ltn1tm1b(EUCOMM)Hmgu/Ccpcz 		increased freezing behavior J:211773
Ltn1tm1b(EUCOMM)Hmgu/Ltn1tm1b(EUCOMM)Hmgu
C57BL/6N-Ltn1tm1b(EUCOMM)Hmgu/Ccpcz 		abnormal cornea morphology J:211773
decreased body weight J:211773
decreased circulating alkaline phosphatase level J:211773
increased airway resistance J:211773
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:211773
increased lung elastance J:211773
increased lung tissue damping J:211773
increased red blood cell distribution width J:211773
no spontaneous movement J:211773
preweaning lethality, incomplete penetrance J:211773
thrombocytopenia J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory