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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Med12
mediator complex subunit 12
MGI:1926212
29 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Med12tm1.1Hsch/Y
involves: 129S6/SvEvTac * C57BL/6NCrl 		no abnormal phenotype detected J:166040
Med12tm1.1Hsch/Med12+
Tg(CMV-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 		abnormal neural tube morphology J:166045
abnormal neurocranium morphology J:166045
abnormal vertebral spinous process morphology J:166045
absent vertebral arch J:166045
craniorachischisis J:166045
curly tail J:166045
embryonic lethality during organogenesis, incomplete penetrance J:166045
exencephaly J:166045
prenatal lethality, incomplete penetrance J:166045
Med12tm1.1Hsch/Med12tm1.1Hsch
involves: 129S6/SvEvTac * C57BL/6NCrl 		no abnormal phenotype detected J:166040
Med12tm1.2Hsch/Y
chimera involves: 129S6/SvEvTac * C57BL/6NCr 		absent anterior visceral endoderm J:166040
embryonic lethality between implantation and somite formation, complete penetrance J:166040
Med12tm1Hsch/Y
chimera involves: 129S6/SvEvTac * C57BL/6NCr 		abnormal dorsal-ventral polarity of the somites J:166040
abnormal first pharyngeal arch morphology J:166040
abnormal head mesenchyme morphology J:166040
abnormal heart development J:166040
abnormal neural crest cell migration J:166040
abnormal neural tube morphology J:166040
abnormal pharyngeal arch morphology J:166040
abnormal somite development J:166040
abnormal somite shape J:166040
absent second pharyngeal arch J:166040
absent third pharyngeal arch J:166040
caudal body truncation J:166040
decreased somite size J:166040
embryonic lethality during organogenesis, complete penetrance J:166040
embryonic lethality, complete penetrance J:166040
failure of heart looping J:166040
kinked neural tube J:166040
open neural tube J:166040
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory