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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cd274
CD274 antigen
MGI:1926446
43 phenotypes from 5 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd274tm1.1Lex/Cd274tm1.1Lex
involves: 129S5/SvEvBrd 		abnormal cytokine secretion J:126829
decreased CD8-positive, alpha-beta T cell number J:126829
increased susceptibility to experimental autoimmune encephalomyelitis J:126829
Cd274tm1Igu/Cd274+
involves: 129 * C57BL/6 * CBA/CaJ 		lethality throughout fetal growth and development, incomplete penetrance J:100544
Cd274tm1Lpc/Cd274tm1Lpc
B6.129S-Cd274tm1Lpc 		abnormal CD8-positive, alpha-beta T cell physiology J:89781
decreased T cell apoptosis J:89781
normal hematopoietic system phenotype J:89781
increased activated T cell number J:89781
increased CD8-positive, alpha-beta T cell number J:89781
increased susceptibility to autoimmune disorder J:89781
Cd274tm1Lpc/Cd274tm1Lpc
C.129S-Cd274tm1Lpc 		abnormal regulatory T cell physiology J:165841
abnormal T follicular helper cell physiology J:165841
decreased germinal center B cell number J:165841
decreased IgG1 level J:165841
decreased IgG2a level J:165841
decreased interleukin-17 secretion J:165841
decreased plasma cell number J:165841
decreased T-helper 17 cell number J:165841
normal immune system phenotype J:165841
increased interferon-gamma secretion J:165841
increased interleukin-4 secretion J:165841
increased susceptibility to induced arthritis J:165841
increased T cell proliferation J:165841
Cd274tm1Lpc/Cd274tm1Lpc
involves: 129S/SvEv 		abnormal chemokine secretion J:158023
hyperresponsive to tactile stimuli J:158023
increased susceptibility to injury J:158023
increased tumor necrosis factor secretion J:158023
Cd274tm1Lpc/Cd274tm1Lpc
involves: 129S/SvEv * C57BL/6 		abnormal dendritic cell physiology J:152305
abnormal T cell morphology J:136330
abnormal T-helper 1 cell differentiation J:162539
decreased susceptibility to Riboviria infection J:136330
decreased susceptibility to Riboviria infection induced morbidity/mortality J:136330
decreased T cell apoptosis J:136330
decreased T helper 1 cell number J:162539
increased CD8-positive, alpha-beta T cell number J:152305
increased IgG1 level J:162539
increased IgG2c level J:162539
increased susceptibility to bacterial infection J:162539
increased susceptibility to bacterial infection induced morbidity/mortality J:162539
increased susceptibility to experimental autoimmune encephalomyelitis J:142815
increased T cell number J:142815
Cd274tm1Shr/Cd274tm1Shr
C.B6-Cd274tm1Shr 		abnormal interleukin secretion J:123785
increased interferon-gamma secretion J:123785
increased susceptibility to autoimmune diabetes J:123785
Cd274tm1Shr/Cd274tm1Shr
involves: C57BL/6 		abnormal CD4-positive, alpha beta T cell morphology J:91480
abnormal CD8-positive, alpha beta T cell morphology J:91480
Cd274tm2Shr/Cd274tm2Shr
involves: 129/Sv * 129S4/SvJae 		abnormal cytokine secretion J:113851
decreased susceptibility to parasitic infection J:113851
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory