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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Huwe1
HECT, UBA and WWE domain containing 1
MGI:1926884
64 phenotypes from 7 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd79atm1(cre)Reth/Cd79a+
Huwe1tm1.1Mak/Y
B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak 		abnormal B cell differentiation J:181705
abnormal class switch recombination J:181705
abnormal humoral immune response J:181705
absent B-1a cells J:181705
decreased B cell proliferation J:181705
decreased follicular B cell number J:181705
decreased IgA level J:181705
decreased IgG1 level J:181705
decreased IgG2a level J:181705
decreased IgG3 level J:181705
decreased IgM level J:181705
decreased marginal zone B cell number J:181705
decreased mature B cell number J:181705
decreased pre-B cell number J:181705
decreased transitional stage B cell number J:181705
increased B cell apoptosis J:181705
increased susceptibility to Riboviria infection J:181705
Huwe1Gt(DC0732)Wtsi/Y
chimera involves: 129P2/OlaHsd 		embryonic growth retardation J:160967
embryonic lethality during organogenesis, incomplete penetrance J:160967
incomplete embryo turning J:160967
microcephaly J:160967
small heart J:160967
Huwe1Gt(P036B01)Wrst/Y
chimera involves: 129S6/SvEvTac * C57BL/6 		abnormal endoderm development J:160967
Huwe1Gt(P125E01)Wrst/Y
chimera involves: 129S2/SvPas 		abnormal developmental patterning J:160967
abnormal gastrulation J:160967
Huwe1tm1.2Mak/Y
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL 		decreased embryo size J:181705
decreased somite size J:181705
embryonic lethality during organogenesis, complete penetrance J:181705
enlarged heart J:181705
Huwe1tm1Alas/Y
Tg(Nes-cre)1Kag/0
involves: 129S7/SvEvBrd 		abnormal brain morphology J:152966
abnormal cerebral cortex morphology J:152966
abnormal dentate gyrus morphology J:152966
abnormal neuronal precursor proliferation J:152966
abnormal stratification in cerebral cortex J:152966
decreased brain size J:152966
increased neuronal precursor cell number J:152966
neonatal lethality J:152966
small cerebellum J:152966
thin cerebral cortex J:152966
Huwe1tm1Alas/Y
Tg(Prm-cre)58Og/0
involves: 129S4/SvJae * 129S7/SvEvBrd 		normal reproductive system phenotype J:323709
Huwe1tm1Alas/Y
Tg(Spo11-cre)1Rsw/0
involves: 129S7/SvEvBrd 		abnormal spermatocyte morphology J:323709
normal reproductive system phenotype J:323709
Huwe1tm1Alas/Y
Tg(Stra8-icre)1Reb/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ 		abnormal caput epididymis morphology J:323709
abnormal male germ cell physiology J:323709
abnormal male meiosis J:323709
abnormal spermatocyte morphology J:323709
abnormal spermatogonia morphology J:323709
arrest of spermatogenesis J:323709
decreased male germ cell number J:323709
decreased testis weight J:323709
increased male germ cell apoptosis J:323709
increased testis apoptosis J:323709
male infertility J:323709
oligozoospermia J:323709
small testis J:323709
Huwe1tm1Wgu/Y
involves: C57BL/6J 		no abnormal phenotype detected J:182446
Huwe1tm1Wgu/Huwe1tm1Wgu
involves: C57BL/6J 		no abnormal phenotype detected J:182446
Huwe1tm1Wgu/Y
Tg(Ins2-cre)23Herr/0
involves: C57BL/6J * CBA/J 		abnormal urinary bladder morphology J:182446
decreased body weight J:182446
decreased circulating insulin level J:182446
decreased pancreatic beta cell number J:182446
disorganized pancreatic islets J:182446
hyperglycemia J:182446
impaired glucose tolerance J:182446
increased circulating glucose level J:182446
polyuria J:182446
premature death J:182446
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory