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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mettl3
methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
MGI:1927165
26 phenotypes from 4 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mettl3em1(IMPC)Tcp/Mettl3em1(IMPC)Tcp
C57BL/6N-Mettl3em1(IMPC)Tcp/Tcp 		preweaning lethality, complete penetrance J:211773
Mettl3em1(IMPC)Tcp/Mettl3em1(IMPC)Tcp
C57BL/6NCrl-Mettl3em1(IMPC)Tcp/TcpMmucd 		embryonic lethality prior to organogenesis J:211773
embryonic lethality prior to tooth bud stage J:211773
Mettl3em1Chhe/Mettl3em1Chhe
Stra8em1(GFP/cre)Smoc/Stra8+
involves: C57BL/6J 		abnormal epigenetic regulation of gene expression J:250428
normal reproductive system phenotype J:250428
Mettl3em1Chhe/Mettl3em1Chhe
Tg(Ddx4-cre)1Dcas/0
involves: C57BL/6J * FVB 		abnormal epigenetic regulation of gene expression J:250428
abnormal male germ cell morphology J:250428
abnormal male germ cell physiology J:250428
abnormal seminiferous tubule epithelium morphology J:250428
abnormal spermatogonia morphology J:250428
abnormal translation J:250428
decreased male germ cell number J:250428
male infertility J:250428
small testis J:250428
Mettl3tm1.1Jhha/Mettl3tm1.1Jhha
Tg(Ddx4-cre)1Dcas/0
involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB 		abnormal ovary morphology J:299108
female infertility J:299108
male infertility J:299108
small testis J:299108
testis degeneration J:299108
Mettl3tm1.1Jhha/Mettl3tm1.1Jhha
Tg(Prm-cre)58Og/0
involves: 129S4/SvJae * 129S4/SvJaeSor * BALB/c * C57BL/6 		normal reproductive system phenotype J:299108
Mettl3tm1.1Jhha/Mettl3tm1.1Jhha
Tg(Stra8-icre)1Reb/0
involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB/NJ 		oligozoospermia J:299108
reduced male fertility J:299108
seminiferous tubule degeneration J:299108
small testis J:299108
Mettl3tm1.1Jhha/Mettl3tm1.1Jhha
Tg(Zp3-cre)93Knw/0
involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * C57BL/6J 		abnormal female meiosis J:299108
abnormal oocyte morphology J:299108
decreased oocyte number J:299108
normal endocrine/exocrine gland phenotype J:299108
female infertility J:299108
Mettl3tm1Jhha/Mettl3tm1Jhha
involves: 129S4/SvJae * C57BL/6 		abnormal egg cylinder morphology J:219587
abnormal embryo development J:219587
embryonic lethality between implantation and placentation, complete penetrance J:219587
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory