Trio Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Trio
triple functional domain (PTPRF interacting)
MGI:1927230

34 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(GFAP-cre)#Mzhu/0 Trio^tm1Mzhu/Trio^tm1Mzhu involves: 129S6/SvEvTac	normal behavior/neurological phenotype	J:165902
	normal nervous system phenotype	J:165902
Tg(Nes-cre)1Kln/0 Trio^tm1Mzhu/Trio^tm1Mzhu involves: 129S6/SvEvTac * C57BL/6 * SJL	abnormal Bergmann glial cell morphology	J:165902
	abnormal cerebellar granule cell migration	J:165902
	abnormal cerebellar granule cell morphology	J:165902
	abnormal cerebellar granule layer morphology	J:165902
	abnormal cerebellum external granule cell layer morphology	J:165902
	abnormal cerebellum lobule morphology	J:165902
	abnormal dentate gyrus morphology	J:165902
	abnormal neuron differentiation	J:165902
	abnormal olfactory bulb mitral cell layer morphology	J:165902
	abnormal rostral migratory stream morphology	J:165902
	absent gastric milk in neonates	J:165902
	ataxia	J:165902
	decreased body weight	J:165902
	decreased brain size	J:165902
	increased neuron apoptosis	J:165902
	limb grasping	J:165902
	neonatal lethality, incomplete penetrance	J:165902
	postnatal growth retardation	J:165902
	postnatal lethality, complete penetrance	J:165902
	small cerebellum	J:165902
	small olfactory bulb	J:165902
Trio^em1(IMPC)H/Trio⁺ C57BL/6NTac-Trio^em1(IMPC)H/H	impaired glucose tolerance	J:211773
Trio^em1(IMPC)H/Trio⁺ C57BL/6NTac-Trio^em1(IMPC)H/H	increased neutrophil cell number	J:211773
Trio^em1(IMPC)H/Trio^em1(IMPC)H C57BL/6NTac-Trio^em1(IMPC)H/H	abnormal embryo size	J:211773
	preweaning lethality, complete penetrance	J:211773
Trio^tm1Mst/Trio^tm1Mst involves: 129S4/SvJae * BALB/c	abnormal dentate gyrus morphology	J:65380
	abnormal myogenesis	J:65380
	abnormal neuronal migration	J:65380
	abnormal olfactory bulb morphology	J:65380
	abnormal skeletal muscle fiber morphology	J:65380
	abnormal skeletal muscle morphology	J:65380
	lethality throughout fetal growth and development, incomplete penetrance	J:65380
	perinatal lethality, complete penetrance	J:65380

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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