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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pals1
protein associated with LIN7 1, MAGUK family member
MGI:1927339
66 phenotypes from 1 allele in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pals1tm1Caw/Pals1+
Emx1tm1(cre)Krj/Emx1+
involves: 129S2/SvPas 		abnormal behavior J:160624
abnormal cerebral cortex morphology J:160624
abnormal neuronal precursor proliferation J:160624
premature neuronal precursor differentiation J:160624
small hippocampus J:160624
Pals1tm1Caw/Pals1+
Tg(rx3-icre)1Mjam/0
Not Specified 		abnormal retina morphology J:184469
Pals1tm1Caw/Pals1tm1Caw
Not Specified 		no abnormal phenotype detected J:160624
Pals1tm1Caw/Pals1tm1Caw
Emx1tm1(cre)Krj/Emx1+
involves: 129S2/SvPas 		abnormal brain morphology J:160624
abnormal cerebral cortex morphology J:160624
abnormal gait J:160624
abnormal neuronal precursor proliferation J:160624
abnormal placing response J:160624
abnormal spatial learning J:160624
normal behavior/neurological phenotype J:160624
decreased body weight J:160624
decreased exploration in new environment J:160624
decreased grip strength J:160624
decreased locomotor activity J:160624
disheveled coat J:160624
increased neuron apoptosis J:160624
jerky movement J:160624
jumpy J:160624
loss of cortex neurons J:160624
normal mortality/aging J:160624
premature neuronal precursor differentiation J:160624
normal reproductive system phenotype J:160624
thin cerebral cortex J:160624
Pals1tm1Caw/Pals1tm1Caw
Tg(rx3-icre)1Mjam/0
Not Specified 		abnormal cell proliferation J:184469
abnormal eye electrophysiology J:184469
abnormal photoreceptor outer segment morphology J:184469
abnormal retina inner plexiform layer morphology J:184469
abnormal retina morphology J:184469
abnormal retina outer limiting membrane morphology J:184469
abnormal retina outer nuclear layer morphology J:184469
abnormal retina photoreceptor layer morphology J:184469
abnormal retina photoreceptor morphology J:184469
abnormal retina rod cell morphology J:184469
abnormal rod electrophysiology J:184469
absent photoreceptor inner segment J:184469
absent photoreceptor outer segment J:184469
astrocytosis J:184469
decreased cell proliferation J:184469
disorganized retina ganglion layer J:184469
disorganized retina outer nuclear layer J:184469
increased retina apoptosis J:184469
increased susceptibility to age-related retinal degeneration J:184469
microgliosis J:184469
microphthalmia J:184469
retina fold J:184469
retina ganglion cell degeneration J:184469
retina outer nuclear layer degeneration J:184469
retina photoreceptor degeneration J:184469
short photoreceptor inner segment J:184469
short photoreceptor outer segment J:184469
thin retina ganglion layer J:184469
thin retina inner plexiform layer J:184469
thin retina outer nuclear layer J:184469
Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Tg(RNU6-RNAi:Mpp5)13Wij/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal cone electrophysiology J:178056
abnormal retina morphology J:178056
abnormal retina neuronal layer morphology J:178056
abnormal retina outer limiting membrane morphology J:178056
abnormal retina outer plexiform layer morphology J:178056
abnormal retina photoreceptor layer morphology J:178056
abnormal rod electrophysiology J:178056
gliosis J:178056
short photoreceptor outer segment J:178056
Tg(RNU6-RNAi:Mpp5)13Wij/0
Tg(rx3-icre)1Mjam/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal cone electrophysiology J:178056
abnormal eye electrophysiology J:178056
abnormal ocular fundus morphology J:178056
abnormal retina bipolar cell morphology J:178056
abnormal retina morphology J:178056
abnormal retina neuronal layer morphology J:178056
abnormal retina outer limiting membrane morphology J:178056
abnormal retina outer plexiform layer morphology J:178056
abnormal retina photoreceptor morphology J:178056
abnormal retina pigment epithelium morphology J:178056
abnormal rod electrophysiology J:178056
disorganized retina inner nuclear layer J:178056
disorganized retina layers J:178056
disorganized retina outer nuclear layer J:178056
disorganized retina outer plexiform layer J:178056
gliosis J:178056
increased neuron apoptosis J:178056
increased vascular permeability J:178056
retina degeneration J:178056
retina photoreceptor degeneration J:178056
short photoreceptor outer segment J:178056
thin retina inner nuclear layer J:178056
thin retina outer nuclear layer J:178056
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory