Gmnn Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gmnn
geminin
MGI:1927344

51 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gmnn^{Gt(XT0615)Wtsi}/Gmnn^{Gt(XT0615)Wtsi} involves: 129P2/OlaHsd	abnormal cell differentiation	J:110696
	abnormal cell nucleus morphology	J:110696
	abnormal mitosis	J:110696
	abnormal preimplantation embryo development	J:110696
	abnormal trophectoderm morphology	J:110696
	absent inner cell mass	J:110696
	embryonic growth arrest	J:110696
	embryonic lethality before implantation, complete penetrance	J:110696
Gmnn^tm1.1Kio/Gmnn^tm1.2Kio Tg(CD2-icre)4Kio/0 involves: 129S4/SvJae * C57BL/10 * CBA/Ca	decreased CD4-positive, alpha-beta T cell number	J:159657
	decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:159657
	decreased CD8-positive, alpha-beta T cell number	J:159657
	decreased DN1 thymic pro-T cell number	J:159657
	decreased DN4 thymocyte number	J:159657
	decreased double-positive T cell number	J:159657
	decreased memory T cell number	J:159657
	decreased T cell proliferation	J:159657
	decreased thymocyte number	J:159657
Gmnn^tm1.2Kio/Gmnn^tm1.2Kio involves: 129S4/SvJae	embryonic lethality between implantation and somite formation, complete penetrance	J:159657
Gmnn^{tm1a(KOMP)Wtsi}/Gmnn⁺ B6JTyr;B6N-Gmnn^{tm1a(KOMP)Wtsi}/Wtsi	abnormal lens morphology	J:165965
	cataract	J:165965
Gmnn^tm1Nyma/Gmnn^tm1Nyma involves: C57BL/6	abnormal cell adhesion	J:123394
	abnormal cell nucleus morphology	J:123394
	abnormal inner cell mass morphology	J:123394
	abnormal preimplantation embryo development	J:123394
	absent trophectoderm	J:123394
	decreased cell proliferation	J:123394
	embryonic lethality before implantation, complete penetrance	J:123394
Gmnn^tm1Tjm/Gmnn⁺ Tg(Nes-cre)1Kln/0 involves: 129/Sv * C57BL/6 * SJL	decreased litter size	J:171716
Gmnn^tm1Tjm/Gmnn^tm1Tjm involves: 129/Sv * C57BL/6 * C57BL/6J	no abnormal phenotype detected	J:171741
Gmnn^tm1Tjm/Gmnn^tm1Tjm Tg(Mx1-cre)1Cgn/0 involves: 129/Sv * C57BL/6 * C57BL/6J * CBA	abnormal bone marrow cell morphology/development	J:171741
	abnormal bone marrow cell physiology	J:171741
	abnormal common lymphocyte progenitor cell morphology	J:171741
	abnormal common myeloid progenitor cell morphology	J:171741
	abnormal megakaryocyte progenitor cell morphology	J:171741
	abnormal proerythroblast morphology	J:171741
	abnormal spleen red pulp morphology	J:171741
	absent erythroid progenitor cell	J:171741
	anemia	J:171741
	decreased bone marrow cell number	J:171741
	decreased erythrocyte cell number	J:171741
	decreased erythroid progenitor cell number	J:171741
	decreased granulocyte number	J:171741
	decreased hematopoietic stem cell proliferation	J:171741
	decreased leukocyte cell number	J:171741
	decreased neutrophil cell number	J:171741
	increased circulating erythropoietin level	J:171741
	increased hematopoietic stem cell number	J:171741
	increased megakaryocyte cell number	J:171741
	premature death	J:171741
	reticulocytopenia	J:171741
	thrombocytosis	J:171741
Gmnn^tm1Tjm/Gmnn^tm1Tjm Tg(Nes-cre)1Kln/0 involves: 129/Sv * C57BL/6 * SJL	normal behavior/neurological phenotype	J:171716
	decreased litter size	J:171716
	normal mortality/aging	J:171716
	normal nervous system phenotype	J:171716

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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