Sirt3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sirt3
sirtuin 3
MGI:1927665

34 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sirt3^{Gt(OST341297)Lex}/Sirt3^{Gt(OST341297)Lex} involves: 129S5/SvEvBrd	increased systemic arterial systolic blood pressure	J:103485
Sirt3^tm1.1Auw/Sirt3^tm1.1Auw Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: C57BL/6 * C57BL/6J * DBA	normal homeostasis/metabolism phenotype	J:207274
Sirt3^tm1.1Auw/Sirt3^tm1.1Auw Tg(ACTA1-cre)79Jme/0 involves: C57BL/6J * SJL	normal homeostasis/metabolism phenotype	J:207274
Sirt3^tm1.1Cxd/Sirt3^tm1.1Cxd involves: 129S6/SvEvTac * Black Swiss * FVB/N	abnormal cell physiology	J:142586
	abnormal cellular respiration	J:142586
	normal mortality/aging	J:142586
Sirt3^tm1.1Fwa/Sirt3^tm1.1Fwa involves: 129/Sv * FVB/N	no abnormal phenotype detected	J:129009
Sirt3^tm1.1Fwa/Sirt3^tm1.1Fwa involves: 129S6/SvEvTac	abnormal cytokine level	J:178653
	abnormal enzyme/coenzyme level	J:178653
	abnormal lipid homeostasis	J:178653
	decreased carbon dioxide production	J:178653
	decreased oxygen consumption	J:178653
	hyperglycemia	J:178653
	increased circulating cholesterol level	J:178653
	increased circulating insulin level	J:178653
	increased circulating interferon-gamma level	J:178653
	increased circulating interleukin-6 level	J:178653
	increased circulating interleukin-10 level	J:178653
	increased circulating interleukin-12 level	J:178653
	increased circulating LDL cholesterol level	J:178653
	increased circulating triglyceride level	J:178653
	increased circulating tumor necrosis factor level	J:178653
	increased circulating VLDL cholesterol level	J:178653
	increased liver cholesterol level	J:178653
	increased liver triglyceride level	J:178653
	increased susceptibility to diet-induced obesity	J:178653
	increased total body fat amount	J:178653
	insulin resistance	J:178653
	liver fibrosis	J:178653
	liver inflammation	J:178653
	macrovesicular hepatic steatosis	J:178653
Sirt3^{tm1b(EUCOMM)Wtsi}/Sirt3^{tm1b(EUCOMM)Wtsi} C57BL/6N-Sirt3^{tm1b(EUCOMM)Wtsi}/H	abnormal gait	J:211773
	increased circulating alanine transaminase level	J:211773
	increased circulating creatine kinase level	J:211773
	vertebral fusion	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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