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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ireb2
iron responsive element binding protein 2
MGI:1928268
59 phenotypes from 5 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ireb2tm1.1Eal/Ireb2tm1.1Eal
B6J.129-Ireb2tm1.1Eal 		abnormal axon morphology J:217335
abnormal cerebellum white matter morphology J:217335
abnormal cerebral cortex morphology J:217335
abnormal corpus callosum morphology J:217335
abnormal dorsal striatum morphology J:217335
abnormal hippocampal pyramidal neuron dendrite morphology J:217335
abnormal hippocampus pyramidal cell morphology J:217335
abnormal iron homeostasis J:217335
abnormal iron level J:217335
abnormal oligodendrocyte morphology J:217335
abnormal Purkinje cell morphology J:217335
abnormal superior colliculus morphology J:217335
abnormal thalamus morphology J:217335
normal behavior/neurological phenotype J:217335
decreased brain iron level J:217335
decreased heart iron level J:217335
decreased hematocrit J:217335
decreased hemoglobin content J:217335
decreased locomotor activity J:217335
decreased mean corpuscular hemoglobin J:217335
decreased mean corpuscular hemoglobin concentration J:217335
decreased mean corpuscular volume J:217335
decreased mean platelet volume J:217335
decreased vertical activity J:217335
impaired coordination J:217335
increased brain iron level J:217335
increased circulating ferritin level J:217335
increased intestinal iron level J:217335
increased kidney iron level J:217335
increased liver iron level J:217335
increased porphyrin level J:217335
increased red blood cell distribution width J:217335
increased thermal nociceptive threshold J:217335
microcytic anemia J:217335
normal nervous system phenotype J:217335
porphyria J:217335
normal skeleton phenotype J:217335
thrombocytopenia J:217335
Ireb2tm1.1Mwh/Ireb2tm1.1Mwh
involves: 129P2/OlaHsd * C57BL/6 * SJL 		no abnormal phenotype detected J:103414
Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL 		abnormal duodenum morphology J:103414
abnormal erythrocyte morphology J:103414
abnormal iron homeostasis J:103414
abnormal locomotor behavior J:103414
decreased erythrocyte cell number J:103414
decreased hematocrit J:103414
decreased hemoglobin content J:103414
decreased spleen iron level J:103414
increased intestinal iron level J:103414
increased liver iron level J:103414
microcytosis J:103414
Ireb2tm1Mwh/Ireb2tm1Mwh
involves: 129P2/OlaHsd * C57BL/6J 		abnormal erythrocyte morphology J:105124
abnormal iron homeostasis J:105124
abnormal locomotor behavior J:103414
normal behavior/neurological phenotype J:105124
decreased hematocrit J:105124
decreased hemoglobin content J:105124
decreased mean corpuscular volume J:105124
decreased spleen iron level J:105124
increased intestinal iron level J:105124
increased liver iron level J:105124
microcytosis J:105124
Ireb2tm1Roua/Ireb2tm1Roua
B6.Cg-Ireb2tm1Roua 		decreased hematocrit J:176655
decreased hemoglobin content J:176655
decreased mean corpuscular hemoglobin J:176655
decreased mean corpuscular hemoglobin concentration J:176655
decreased mean corpuscular volume J:176655
decreased spleen iron level J:176655
increased liver iron level J:176655
microcytosis J:176655
Ireb2tm1Roua/Ireb2tm1Roua
involves: C57BL/6 		abnormal cerebellum morphology J:67313
abnormal corpora quadrigemina morphology J:67313
abnormal gait J:67313
abnormal iron homeostasis J:87889
abnormal locomotor behavior J:67313
abnormal posture J:67313
abnormal thalamus morphology J:67313
abnormal vestibular system physiology J:67313
ataxia J:67313
bradykinesia J:67313
decreased grip strength J:67313
decreased Purkinje cell number J:67313
impaired balance J:67313
increased brain iron level J:67313
increased circulating ferritin level J:67313
increased intestinal iron level J:67313
increased liver iron level J:67313
kyphosis J:67313
normal liver/biliary system phenotype J:67313
Purkinje cell degeneration J:67313
tremors J:67313
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory