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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mtor
mechanistic target of rapamycin kinase
MGI:1928394
135 phenotypes from 14 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mtorchino/Mtorchino
involves: C57BL/6JAnu 		decreased body size J:207898
decreased CD4-positive, alpha-beta T cell number J:207898
decreased splenocyte number J:207898
normal immune system phenotype J:207898
Mtorflat/Mtorflat
involves: BTBR/J * C57BL/6J 		abnormal diencephalon morphology J:53291
abnormal embryonic neuroepithelium morphology J:53291
abnormal forebrain morphology J:53291
abnormal midbrain morphology J:53291
absent embryonic telencephalon J:53291
decreased embryo size J:53291
embryonic growth retardation J:53291
embryonic lethality, complete penetrance J:53291
forebrain hypoplasia J:53291
incomplete embryo turning J:53291
Mtorflat/Mtorflat
Not Specified 		abnormal embryonic tissue morphology J:94381
absent embryonic telencephalon J:94381
decreased embryo size J:94381
embryonic growth arrest J:94381
embryonic growth retardation J:94381
incomplete embryo turning J:94381
MtorGt(OST92090)Lex/MtorGt(OST92090)Lex
involves: 129S5/SvEvBrd 		abnormal trophoblast giant cell morphology J:137592
absent inner cell mass proliferation J:137592
Mtortm1.1Clyn/Mtor+
involves: BALB/c * C57BL/6J 		abnormal muscle physiology J:162945
decreased circulating insulin-like growth factor I level J:162945
decreased lean body mass J:162945
decreased skeletal muscle weight J:162945
increased total body fat amount J:162945
Mtortm1.1Clyn/Mtortm1.1Clyn
involves: BALB/c * C57BL/6J 		embryonic lethality J:162945
Mtortm1.1Gcon/Mtortm1.1Gcon
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal autophagy J:163763
abnormal mitochondrial physiology J:163763
abnormal myocardial fiber morphology J:163763
abnormal myocardial fiber physiology J:163763
abnormal sarcomere morphology J:163763
abnormal translation J:163763
ascites J:163763
cardiac interstitial fibrosis J:163763
congestive heart failure J:163763
decreased cardiac muscle contractility J:163763
decreased heart left ventricle wall thickness J:163763
decreased heart ventricle muscle contractility J:163763
decreased myocardial fiber size J:163763
dilated cardiomyopathy J:163763
dilated mitochondrion J:163763
enlarged heart J:163763
increased cardiomyocyte apoptosis J:163763
increased heart atrium size J:163763
increased heart ventricle size J:163763
increased response of heart to induced stress J:163763
pleural effusion J:163763
premature death J:163763
thin interventricular septum J:163763
Mtortm1.1Koz/Mtor+
either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6) 		no abnormal phenotype detected J:94133
Mtortm1.1Koz/Mtortm1.1Koz
either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6) 		abnormal developmental patterning J:94133
abnormal embryonic tissue morphology J:94133
abnormal extraembryonic tissue morphology J:94133
abnormal trophoblast layer morphology J:94133
embryonic growth arrest J:94133
embryonic growth retardation J:94133
embryonic lethality during organogenesis, complete penetrance J:94133
inner cell mass degeneration J:94133
small ectoplacental cone J:94133
Mtortm1.1Lgm/Mtortm1.1Lgm
involves: 129S1/Sv * C57BL/6 		normal growth/size/body region phenotype J:168600
normal immune system phenotype J:168600
Mtortm1.1Seq/Mtortm1.2Seq
Tg(Nphs2-cre)1Seq/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal cell morphology J:184667
abnormal podocyte morphology J:184667
abnormal renal glomerular capsule morphology J:184667
abnormal renal glomerulus morphology J:184667
abnormal renal tubule morphology J:184667
abnormal urine homeostasis J:184667
increased glomerular capsule space J:184667
podocyte foot process effacement J:184667
postnatal growth retardation J:184667
Mtortm1.2Koz/Mtortm1.2Koz
Tg(ACTA1-cre)79Jme/?
involves: 129S4/SvJae * C57BL/6J * SJL 		abnormal diaphragm morphology J:162918
abnormal gastrocnemius morphology J:162918
abnormal limb muscle morphology J:162918
abnormal limb posture J:162918
abnormal muscle contractility J:162918
abnormal muscle morphology J:162918
abnormal muscle physiology J:162918
abnormal muscle relaxation J:162918
abnormal oxygen consumption J:162918
abnormal skeletal muscle fiber morphology J:162918
abnormal soleus morphology J:162918
abnormal tibialis anterior morphology J:162918
centrally nucleated skeletal muscle fibers J:162918
decreased body weight J:162918
decreased circulating glucose level J:162918
decreased mitochondrial number J:162918
decreased oxygen consumption J:162918
decreased respiration J:162918
increased muscle fatigability J:162918
increased skeletal muscle glycogen level J:162918
kyphosis J:162918
postnatal growth retardation J:162918
premature death J:162918
skeletal muscle degeneration J:162918
skeletal muscle fiber degeneration J:162918
Mtortm1.2Koz/Mtortm1.2Koz
Tg(Cd4-cre)1Cwi/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 		abnormal T cell differentiation J:150108
abnormal T cell subpopulation ratio J:150108
abnormal thymus cell ratio J:150108
decreased interferon-gamma secretion J:150108
decreased interleukin-2 secretion J:150108
decreased interleukin-17 secretion J:150108
decreased T cell proliferation J:150108
decreased tumor necrosis factor secretion J:150108
increased regulatory T cell number J:150108
Mtortm1.2Seq/Mtortm1.2Seq
involves: C57BL/6 * SJL 		prenatal lethality, complete penetrance J:184667
Mtortm1a(EUCOMM)Wtsi/Mtor+
C57BL/6N-Mtortm1a(EUCOMM)Wtsi/Wtsi 		decreased blood urea nitrogen level J:175295
decreased circulating LDL cholesterol level J:175295
increased circulating LDL cholesterol level J:175295
increased mean corpuscular hemoglobin J:175295
Mtortm1a(EUCOMM)Wtsi/Mtortm1a(EUCOMM)Wtsi
C57BL/6N-Mtortm1a(EUCOMM)Wtsi/Wtsi 		preweaning lethality, complete penetrance J:211773
Mtortm1Koz/Mtortm1Koz
Cnptm1(cre)Kan/Cnp+
involves: 129S4/SvJae * C57BL/6 		abnormal axolemma morphology J:181341
abnormal axon morphology J:181341
abnormal internode morphology J:181341
abnormal motor coordination/balance J:181341
abnormal myelin sheath morphology J:181341
abnormal myelination J:181341
abnormal Schwann cell morphology J:181341
decreased nerve conduction velocity J:181341
decreased Schwann cell number J:181341
Mtortm1Lgm/Mtortm1Lgm
involves: 129S1/Sv * C57BL/6 		abnormal B cell physiology J:168600
abnormal humoral immune response J:168600
abnormal T cell morphology J:168600
abnormal T cell physiology J:168600
decreased B cell number J:168600
decreased B cell proliferation J:168600
decreased body size J:168600
decreased body weight J:168600
decreased double-positive T cell number J:168600
decreased follicular B cell number J:168600
decreased IgG level J:168600
decreased IgM level J:168600
decreased marginal zone B cell number J:168600
decreased monocyte cell number J:168600
decreased neutrophil cell number J:168600
decreased plasma cell number J:168600
decreased splenocyte apoptosis J:168600
decreased splenocyte proliferation J:168600
decreased thymocyte number J:168600
decreased transitional stage T1 B cell number J:168600
impaired B cell migration J:168600
increased CD4-positive, alpha-beta T cell number J:168600
increased CD8-positive, alpha-beta T cell number J:168600
preweaning lethality, incomplete penetrance J:168600
small spleen J:168600
Mtortm1Yam/Mtortm1Yam
involves: 129S4/SvJae 		abnormal gastrulation J:92252
abnormal trophoblast layer morphology J:92252
absent inner cell mass proliferation J:92252
embryonic lethality between implantation and somite formation, complete penetrance J:92252
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory