Tdo2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tdo2
tryptophan 2,3-dioxygenase
MGI:1928486

21 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tdo2^{tm1b(KOMP)Mbp}/Tdo2⁺ C57BL/6N-Tdo2^{tm1b(KOMP)Mbp}/Tcp	abnormal heart morphology	J:211773
	abnormal uterus morphology	J:211773
	enlarged heart	J:211773
	hydrometra	J:211773
	increased heart weight	J:211773
	increased prepulse inhibition	J:211773
Tdo2^{tm1b(KOMP)Mbp}/Tdo2^{tm1b(KOMP)Mbp} C57BL/6N-Tdo2^{tm1b(KOMP)Mbp}/Tcp	abnormal embryo size	J:211773
	edema	J:211773
	microphthalmia	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Tdo2^tm1Tnak/Tdo2^tm1Tnak B6.129-Tdo2^tm1Tnak	abnormal amino acid level	J:177903
	abnormal circulating amino acid level	J:177903
	abnormal neuron differentiation	J:177903
	abnormal neuronal precursor proliferation	J:177903
	abnormal olfactory bulb development	J:177903
	normal behavior/neurological phenotype	J:177903
	decreased anxiety-related response	J:177903
	increased circulating methionine level	J:177903
	increased circulating threonine level	J:177903
	increased serotonin level	J:177903
	small lateral ventricles	J:177903

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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