Usp14 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Usp14
ubiquitin specific peptidase 14
MGI:1928898

61 phenotypes from 3 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Usp14^ax-J/Usp14^ax-J B6.Cg-Usp14^ax-J	abnormal neuromuscular synapse morphology	J:203043
	decreased body weight	J:203043
	premature death	J:203043
Usp14^ax-J/Usp14^ax-J B6.Cg-Usp14^ax-J/J	abnormal cerebellar granule cell morphology	J:108034
	abnormal miniature endplate potential	J:79322
	abnormal neurotransmitter secretion	J:79322
	abnormal synaptic transmission	J:79322
	decreased paired-pulse facilitation	J:79322, J:142436
	decreased post-tetanic potentiation	J:79322
	impaired synaptic plasticity	J:79322
	increased neuron apoptosis	J:108034
	increased synaptic depression	J:142436
	reduced long-term potentiation	J:79322
Usp14^ax-J/Usp14^ax-J C.Cg-Usp14^ax-J	abnormal motor capabilities/coordination/movement	J:203043
	ataxia	J:203043
	premature death	J:203043
	progressive muscle weakness	J:203043
Usp14^ax-J/Usp14^ax-J involves: STOCK Mafb^kr	abnormal brain commissure morphology	J:12283
	abnormal brain morphology	J:12283
	abnormal cingulum morphology	J:12283
	abnormal dentate gyrus morphology	J:6389
	abnormal hindbrain morphology	J:12283
	abnormal hippocampus pyramidal cell morphology	J:6389
	abnormal limbic system morphology	J:12283
	abnormal lumbar vertebrae morphology	J:12283
	abnormal pons morphology	J:12283
	abnormal pontine nuclei morphology	J:12283
	abnormal spinal cord white matter morphology	J:12283
	abnormal spinal nerve morphology	J:12283
	ataxia	J:12283, J:27868
	decreased body size	J:12283, J:27868
	decreased corpus callosum size	J:12283
	decreased hippocampal commissure size	J:12283
	decreased midbrain size	J:12283
	female infertility	J:27868
	normal homeostasis/metabolism phenotype	J:5066
	male infertility	J:27868
	muscular atrophy	J:12283
	paralysis	J:12283, J:27868
	postnatal growth retardation	J:27868
	premature death	J:27868
	priapism	J:12283
	Purkinje cell degeneration	J:12283
	short lumbar vertebrae	J:12283
	small cerebellum	J:12283
	small hippocampus	J:6389
	tremors	J:12283, J:27868
	weakness	J:12283, J:27868
Usp14^nmf375/Usp14^nmf375 B6(C)-Usp14^nmf375	perinatal lethality, complete penetrance	J:203043
Usp14^nmf375/Usp14^nmf375 B6;CByJ-Usp14^nmf375/J	abnormal brainstem morphology	J:87349
	abnormal spinal cord morphology	J:87349
	axonal dystrophy	J:87349
	decreased body size	J:87349
	limb grasping	J:87349
	muscle degeneration	J:87349
	muscle spasm	J:87349
	paraparesis	J:87349
Usp14^nmf375/Usp14^nmf375 C.B6-Usp14^nmf375	abnormal nervous system physiology	J:203043
	abnormal neuromuscular synapse morphology	J:203043
	normal behavior/neurological phenotype	J:203043
	decreased body size	J:203043
	decreased body weight	J:203043
	impaired coordination	J:203043
	increased mechanical nociceptive threshold	J:203043
	normal muscle phenotype	J:203043
	muscle weakness	J:203043
	normal nervous system phenotype	J:203043
	premature death	J:203043
Usp14^{tm2b(EUCOMM)Wtsi}/Usp14^{tm2b(EUCOMM)Wtsi} C57BL/6N-Usp14^{tm2b(EUCOMM)Wtsi}/H	preweaning lethality, complete penetrance	J:211773

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