About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Stk4
serine/threonine kinase 4
MGI:1929004
55 phenotypes from 12 alleles in 14 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
B6.129P2-Stk4Gt(AJ0315)Wtsi 		abnormal memory T cell number J:142674
abnormal T cell differentiation J:142674
decreased CD4-positive, alpha-beta T cell number J:142674
decreased CD8-positive, alpha-beta T cell number J:142674
decreased spleen white pulp amount J:142674
increased interferon-gamma secretion J:142674
increased interleukin-2 secretion J:142674
increased interleukin-4 secretion J:142674
increased T cell apoptosis J:142674
increased T cell proliferation J:142674
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
involves: 129 * C57BL/6 		increased histiocytic sarcoma incidence J:153945
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
involves: 129P2/OlaHsd * C57BL/6J 		normal mortality/aging J:140710
Stk4m1Btlr/Stk4m1Btlr
C57BL/6J-Stk4m1Btlr 		abnormal humoral immune response J:265233
decreased B cell number J:265233
decreased CD4-positive, alpha-beta T cell number J:265233
decreased CD8-positive, alpha-beta T cell number J:265233
decreased IgD level J:265233
decreased single-positive T cell number J:265233
decreased T cell number J:265233
increased IgE level J:265233
increased IgM level J:265233
increased macrophage cell number J:265233
increased neutrophil cell number J:265233
increased NK cell number J:265233
Stk4m1Mhda/Stk4+
C3HeB/FeJ-Stk4m1Mhda 		no abnormal phenotype detected J:82809
Stk4m2Btlr/Stk4m2Btlr
C57BL/6J-Stk4m2Btlr 		decreased B-1 B cell number J:265237
decreased B-2 B cell number J:265237
decreased CD4-positive, alpha-beta T cell number J:265237
decreased CD8-positive, alpha-beta T cell number J:265237
decreased CD8-positive, naive alpha-beta T cell number J:265237
decreased IgD level J:265237
decreased single-positive T cell number J:265237
decreased T cell number J:265237
increased B-1b cell number J:265237
increased central memory CD4-positive, alpha-beta T cell number J:265237
increased central memory CD8 positive, alpha-beta T cell number J:265237
increased dendritic cell number J:265237
increased effector memory CD4-positive, alpha-beta T cell number J:265237
increased effector memory CD8-positive, alpha-beta T cell number J:265237
increased IgE level J:265237
increased macrophage cell number J:265237
increased neutrophil cell number J:265237
increased NK cell number J:265237
Stk4m3Btlr/Stk4m3Btlr
C57BL/6J-Stk4m3Btlr 		decreased CD4-positive, alpha-beta T cell number J:265245
decreased CD8-positive, alpha-beta T cell number J:265245
decreased single-positive T cell number J:265245
decreased T cell number J:265245
Stk4m4Btlr/Stk4m4Btlr
C57BL/6J-Stk4m4Btlr 		decreased CD11b-high dendritic cell number J:272536
decreased IgD level J:272536
decreased IgG level J:272536
impaired humoral immune response J:272536
increased B-1b cell number J:272536
increased dendritic cell number J:272536
Stk4m5Btlr/Stk4m5Btlr
C57BL/6J-Stk4m5Btlr 		abnormal CD4-positive T cell differentiation J:272743
abnormal T cell differentiation J:272743
decreased CD4-positive, alpha-beta T cell number J:272743
increased central memory CD4-positive, alpha-beta T cell number J:272743
Stk4tm1.1Kina/Stk4tm1.1Kina
involves: C57BL/6 		abnormal B cell physiology J:148791
abnormal dendritic cell physiology J:148791
abnormal immune system organ morphology J:148791
abnormal leukocyte adhesion J:148791
abnormal leukocyte migration J:148791
abnormal marginal zone B cell morphology J:148791
abnormal Peyer's patch germinal center morphology J:148791
abnormal Peyer's patch T cell area morphology J:148791
abnormal spleen B cell follicle morphology J:148791
abnormal T cell physiology J:148791
decreased B cell number J:148791
decreased lymphocyte cell number J:148791
decreased marginal zone B cell number J:148791
decreased myeloid dendritic cell number J:148791
decreased spleen B cell follicle size J:148791
decreased T cell number J:148791
increased single-positive T cell number J:148791
increased T cell proliferation J:148791
thymus hyperplasia J:148791
Stk4tm1.1Wtao/Stk4tm1.2Wtao
Tg(Lck-cre)#Zhu/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL/J 		decreased CD4-positive, alpha-beta T cell number J:152323
decreased CD8-positive, alpha-beta T cell number J:152323
decreased T cell number J:152323
increased single-positive T cell number J:152323
increased thymocyte number J:152323
Stk4tm1.1Yy/Stk4tm1.1Yy
involves: C57BL/6 * CBA 		no abnormal phenotype detected J:156541
Stk4tm1.2Wtao/Stk4tm1.2Wtao
involves: 129S4/SvJaeSor * 129S6/SvEvTac 		abnormal CD4-positive, alpha-beta T cell physiology J:152323
abnormal CD8-positive, alpha-beta T cell physiology J:152323
abnormal T cell physiology J:152323
decreased B cell number J:152323
decreased CD4-positive, alpha-beta T cell number J:152323
decreased CD8-positive, alpha-beta T cell number J:152323
decreased lymphocyte cell number J:152323
increased single-positive T cell number J:152323
increased thymocyte number J:152323
Stk4tm1Dlim/Stk4tm1Dlim
Not Specified 		abnormal T cell physiology J:155001
decreased T cell number J:155001
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory