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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Stk4
serine/threonine kinase 4
MGI:1929004
69 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Stk3tm1.1Jav/Stk3+
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
involves: 129 * C57BL/6 		increased hepatocellular carcinoma incidence J:153945
lethargy J:153945
liver hyperplasia J:153945
Stk3tm1.1Jav/Stk3tm1.1Jav
Stk4Gt(AJ0315)Wtsi/Stk4+
involves: 129 * C57BL/6 		increased hepatocellular carcinoma incidence J:153945
Stk3tm1.1Jav/Stk3tm1.1Jav
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
involves: 129 * C57BL/6 		abnormal vitelline vasculature morphology J:153945
decreased embryo size J:153945
embryonic growth retardation J:153945
embryonic lethality during organogenesis, complete penetrance J:153945
enlarged pericardium J:153945
failure of initiation of embryo turning J:153945
open neural tube J:153945
pale yolk sac J:153945
Stk3tm1.1Jav/Stk3tm1.1Jav
Stk4tm1Kina/Stk4tm1Kina
Tg(Nkx2-1-cre)2Sand/?
involves: 129 * C57BL/6 		abnormal lung development J:197340
abnormal pulmonary alveolus morphology J:197340
emphysema J:197340
increased lung endothelial cell proliferation J:197340
lung inflammation J:197340
postnatal lethality J:197340
primary atelectasis J:197340
pulmonary hyaline membrane formation J:197340
Stk3tm1.1Jav/Stk3tm1Jav
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
involves: 129 * C57BL/6 		decreased sensitivity to induced cell death J:153945
increased hepatocellular carcinoma incidence J:153945
increased hepatocyte proliferation J:153945
liver hyperplasia J:153945
Stk3tm1.1Rjo/Stk3tm1.1Rjo
Stk4tm1.1Rjo/Stk4tm1.1Rjo
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL 		abnormal hepatocyte morphology J:156531
abnormal liver morphology J:156531
abnormal liver sinusoid morphology J:156531
normal homeostasis/metabolism phenotype J:156531
increased hepatocellular carcinoma incidence J:156531
increased hepatocyte apoptosis J:156531
increased hepatocyte proliferation J:156531
increased liver tumor incidence J:156531
increased liver weight J:156531
Stk3tm1.1Yy/Stk3+
Stk4tm1.1Yy/Stk4tm1.1Yy
involves: C57BL/6 * CBA 		abnormal liver physiology J:156541
abnormal response/metabolism to endogenous compounds J:156541
decreased circulating alanine transaminase level J:156541
decreased circulating aspartate transaminase level J:156541
decreased hepatocyte apoptosis J:156541
decreased susceptibility to induced morbidity/mortality J:156541
Stk3tm1.1Yy/Stk3tm1.1Yy
Stk4tm1.1Yy/Stk4tm1.1Yy
involves: C57BL/6 * CBA 		abnormal embryo development J:156541
decreased fibroblast apoptosis J:156541
decreased hepatocyte apoptosis J:156541
embryonic growth retardation J:156541
embryonic lethality during organogenesis, complete penetrance J:156541
Stk3tm1.1Yy/Stk3tm1Yy
Stk4tm1.1Yy/Stk4tm1.1Yy
involves: C57BL/6 * CBA 		abnormal liver physiology J:156541
abnormal response/metabolism to endogenous compounds J:156541
decreased circulating alanine transaminase level J:156541
decreased circulating aspartate transaminase level J:156541
decreased hepatocyte apoptosis J:156541
decreased susceptibility to induced morbidity/mortality J:156541
Stk3tm1.1Yy/Stk3tm1Yy
Stk4tm1.1Yy/Stk4tm1.1Yy
involves: C57BL/6 * CBA 		increased circulating alanine transaminase level J:156541
increased circulating aspartate transaminase level J:156541
increased liver tumor incidence J:156541
Stk3tm1.1Yy/Stk3tm1Yy
Stk4tm1.1Yy/Stk4tm1.1Yy
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: C57BL/6 * CBA * DBA 		abnormal hepatocyte morphology J:156541
abnormal liver morphology J:156541
enlarged liver J:156541
increased hepatocyte apoptosis J:156541
increased hepatocyte proliferation J:156541
Stk3tm1.1Yy/Stk3tm1Yy
Stk4tm1.1Yy/Stk4tm1.1Yy
Tg(CAG-cre/Esr1*)5Amc/0
involves: C57BL/6 * CBA 		enlarged heart J:156541
enlarged liver J:156541
enlarged spleen J:156541
enlarged stomach J:156541
increased carcinoma incidence J:156541
increased hepatocellular carcinoma incidence J:156541
increased hepatocyte proliferation J:156541
increased liver tumor incidence J:156541
Stk3tm1Dlim/Stk3tm1Dlim
Stk4tm1Dlim/Stk4tm1Dlim
Not Specified 		abnormal angiogenesis J:155001
abnormal blood vessel morphology J:155001
abnormal cell proliferation J:155001
abnormal chorion morphology J:155001
abnormal embryo development J:155001
abnormal embryonic hematopoiesis J:155001
abnormal embryonic neuroepithelium morphology J:155001
abnormal heart development J:155001
abnormal neural plate morphology J:155001
abnormal placenta development J:155001
abnormal placenta labyrinth morphology J:155001
abnormal placental labyrinth vasculature morphology J:155001
abnormal placental transport J:155001
abnormal vascular branching morphogenesis J:155001
abnormal vascular endothelial cell morphology J:155001
abnormal vitelline vasculature morphology J:155001
decreased embryo size J:155001
decreased trophoblast giant cell number J:155001
embryonic growth retardation J:155001
embryonic lethality during organogenesis, complete penetrance J:155001
incomplete embryo turning J:155001
increased embryonic tissue cell apoptosis J:155001
increased placenta apoptosis J:155001
small ectoplacental cone J:155001
Stk3tm1Jav/Stk3tm1Jav
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
involves: 129 * C57BL/6 		increased hepatocellular carcinoma incidence J:153945
increased hepatocyte proliferation J:153945
liver hyperplasia J:153945
Stk3tm1Jav/Stk3tm1Jav
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129 * 129P2/OlaHsd * C57BL/6 * DBA 		increased hepatocellular carcinoma incidence J:238319
Stk3tm1Jav/Stk3tm1Jav
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129 * C57BL/6 		increased hepatocellular carcinoma incidence J:153945
liver hyperplasia J:153945
Stk3tm1Jav/Stk3tm1Jav
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Tg(KRT14-cre)1Amc/0
involves: C57BL/6 * CBA 		normal integument phenotype J:171057
Stk3tm1Yy/Stk3tm1.1Yy
Stk4tm1.1Yy/Stk4tm1.1Yy
Tg(Prrx1-cre)1Cjt/0
involves: C57BL/6 * CBA * SJL 		abnormal cartilage morphology J:156541
abnormal limb bone morphology J:156541
abnormal long bone hypertrophic chondrocyte zone J:156541
abnormal skeleton physiology J:156541
decreased length of long bones J:156541
short limbs J:156541
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory