Tsc1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tsc1
TSC complex subunit 1
MGI:1929183

22 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Lin28a^tm1.1Gqda/Lin28a^tm1.1Gqda Tsc1^tm1.1Djk/Tsc1⁺ involves: 129S4/SvJae * C57BL/6	decreased body size	J:199720
	neonatal lethality, incomplete penetrance	J:199720
Lin28b^tm1.1Gqda/Lin28b^tm1.1Gqda Tsc1^tm1.1Djk/Tsc1⁺ involves: 129S4/SvJae * C57BL/6 * FVB	normal growth/size/body region phenotype	J:199720
Lin28b^tm1Gqda/Lin28b^tm1Gqda Myf5^tm1(cre)Mrc/Myf5⁺ Tsc1^tm1Djk/Tsc1⁺ involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	normal growth/size/body region phenotype	J:199720
Nf1^tm1Fcr/Nf1⁺ Tsc1^tm1Djk/Tsc1^tm1Djk Tg(GFAP-cre)#Gtm/0 involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA	normal neoplasm	J:176586
	premature death	J:176586
Pdpk1^tm1Maka/Pdpk1^tm1Maka Tsc1^tm1Djk/Tsc1^tm1Djk Tg(Gdf9-icre)5092Coo/? involves: 129S4/SvJae * C57BL/6J	abnormal ovarian follicle morphology	J:155357
Pten^tm1Hwu/Pten^tm1Hwu Tsc1^tm1Djk/Tsc1^tm1Djk Tg(Gdf9-icre)5092Coo/? involves: 129S4/SvJae * C57BL/6J	abnormal ovarian follicle morphology	J:155357
Rheb^tm1.1Yelg/Rheb⁺ Tsc1^tm1Chdl/Tsc1^tm1Chdl B6.129P2-Tsc1^tm1Chdl Rheb^tm1.1Yelg	decreased fetal size	J:170999
	fetal growth retardation	J:170999
	increased embryonic tissue cell apoptosis	J:170999
	lethality throughout fetal growth and development, complete penetrance	J:170999
Slc38a1^tm1.1Ttaka/Slc38a1^tm1.1Ttaka Tsc1^tm1Djk/Tsc1⁺ Tg(Syn1-cre)671Jxm/0 involves: 129S4/SvJae * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj	normal nervous system phenotype	J:288818
Trp53^tm1Brn/Trp53^tm1Brn Tsc1^tm1Djk/Tsc1^tm1Djk involves: 129P2/OlaHsd * 129S4/SvJae	hemorrhagic ascites	J:212578
	increased mesothelioma incidence	J:212578
	premature death	J:212578
Tsc1^tm1Djk/Tsc1^tm1Djk Gt(ROSA)26Sor^tm1Sho/Gt(ROSA)26Sor⁺ involves: 129S4/SvJae * 129S4/SvJaeSor	abnormal brain morphology	J:221022
	abnormal brain ventricle morphology	J:221022
	abnormal neuron morphology	J:221022
	abnormal postnatal subventricular zone morphology	J:221022
	cachexia	J:221022
	enlarged lateral ventricles	J:221022
	hunched posture	J:221022
	hydrocephaly	J:221022
	increased brain size	J:221022
	premature death	J:221022

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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