Cldn18 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cldn18
claudin 18
MGI:1929209

27 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cldn18^{tm1(KOMP)Vlcg}/Cldn18^{tm1(KOMP)Vlcg} involves: C57BL/6J * C57BL/6NTac	abnormal pulmonary alveolar system morphology	J:232069
	abnormal pulmonary alveolus epithelium morphology	J:232069
	impaired lung alveolus development	J:232069
	increased type II pneumocyte number	J:232069
Cldn18^{tm1.1(KOMP)Vlcg}/Cldn18^{tm1.1(KOMP)Vlcg} C57BL/6N-Cldn18^{tm1.1(KOMP)Vlcg}/Ucd	abnormal lung morphology	J:211773
	abnormal uterus morphology	J:211773
	enlarged lung	J:211773
	increased lung weight	J:211773
	increased red blood cell distribution width	J:211773
Cldn18^tm1Lex/Cldn18^tm1Lex involves: 129S5/SvEvBrd	abnormal gastric chief cell morphology	J:195931
	abnormal gastric parietal cell morphology	J:195931
	abnormal osteoclast differentiation	J:195931
	abnormal stomach mucosa morphology	J:195931
	abnormal trabecular bone morphology	J:195931
	decreased bone mass	J:195931
	decreased bone mineral content	J:195931
	decreased bone mineral density	J:195931
	decreased bone strength	J:195931
	decreased bone trabecula number	J:195931
	decreased compact bone thickness	J:195931
	decreased trabecular bone connectivity density	J:195931
	decreased trabecular bone thickness	J:195931
	decreased trabecular bone volume	J:195931
	normal homeostasis/metabolism phenotype	J:195931
	increased bone resorption	J:195931
	increased osteoclast cell number	J:195931
	normal skeleton phenotype	J:195931

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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