Rabgef1 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rabgef1
RAB guanine nucleotide exchange factor (GEF) 1
MGI:1929459

14 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rabgef1^tm1Glli/Rabgef1^tm1Glli either: (involves: 129P2/OlaHsd * 129S/SvEv) or (involves: 129P2/OlaHsd * C57BL/6)	abnormal dermal layer morphology	J:91790
	abnormal epidermal layer morphology	J:91790
	abnormal inflammatory response	J:91790
	abnormal keratinocyte morphology	J:91790
	abnormal mast cell morphology	J:91790
	chronic inflammation	J:91790
	cutaneous mastocytosis	J:91790
	epidermal hyperplasia	J:91790
	increased circulating histamine level	J:91790
	increased IgE level	J:91790
	increased interleukin-6 secretion	J:91790
	increased tumor necrosis factor secretion	J:91790
	postnatal lethality, incomplete penetrance	J:91790
Rabgef1^tm2Glli/Rabgef1^tm2Glli WBB6F1	increased interleukin-6 secretion	J:91790
	increased tumor necrosis factor secretion	J:91790
	neonatal lethality, complete penetrance	J:91790

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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