Tyk2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tyk2
tyrosine kinase 2
MGI:1929470

44 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tyk2^E775K/Tyk2^E775K B10.D1-H2^q/SgJ	abnormal T-helper 1 physiology	J:69051
	decreased IgG1 level	J:69051
	decreased IgG2a level	J:69051
	decreased IgG level	J:69051
	decreased interferon-gamma secretion	J:69051, J:120304
	decreased susceptibility to induced arthritis	J:69051
	increased circulating interleukin-12 level	J:120304
	increased susceptibility to parasitic infection	J:120304
Tyk2^tm1Biat/Tyk2^tm1Biat B6NCrl.129P2-Tyk2^tm1Biat	increased susceptibility to Picornaviridae infection induced morbidity/mortality	J:187818
Tyk2^tm1Biat/Tyk2^tm1Biat B6NCrl.129P2-Tyk2^tm1Biat	increased susceptibility to Riboviria infection induced morbidity/mortality	J:187818
Tyk2^tm1Biat/Tyk2^tm1Biat involves: 129P2/OlaHsd * C57BL/6	abnormal nitric oxide homeostasis	J:116703
	abnormal response to infection	J:116703
	decreased interferon-gamma secretion	J:65408
	decreased macrophage nitric oxide production	J:65408
	increased susceptibility to Herpesvirales infection	J:116703
	increased susceptibility to Herpesvirales infection induced morbidity/mortality	J:116703
	increased susceptibility to Riboviria infection	J:65408
	increased susceptibility to viral infection induced morbidity/mortality	J:65408
Tyk2^tm1Shmd/Tyk2^tm1Shmd either: (involves: 129 * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)	abnormal body temperature homeostasis	J:195099
	abnormal brown adipose tissue morphology	J:195099
	abnormal fat cell differentiation	J:195099
	abnormal mitochondrial physiology	J:195099
	decreased energy expenditure	J:195099
	disorganized mitochondrial cristae	J:195099
	impaired adaptive thermogenesis	J:195099
	impaired glucose tolerance	J:195099
	increased body weight	J:195099
	increased cholesterol level	J:195099
	increased circulating free fatty acids level	J:195099
	increased circulating insulin level	J:195099
	obese	J:195099
Tyk2^tm1Shmd/Tyk2^tm1Shmd involves: 129P2/OlaHsd	abnormal cell cycle	J:109408
	abnormal common myeloid progenitor cell morphology	J:109408
	abnormal splenocyte physiology	J:65409
	abnormal T cell differentiation	J:65409
	abnormal T cell physiology	J:65409
	decreased interferon-gamma secretion	J:65409
Tyk2^{tm2b(EUCOMM)Hmgu}/Tyk2^{tm2b(EUCOMM)Hmgu} C57BL/6N-Tyk2^{tm2b(EUCOMM)Hmgu}/Ieg	abnormal ovary morphology	J:211773
	abnormal pancreas morphology	J:211773
	abnormal seminal vesicle morphology	J:211773
	decreased circulating HDL cholesterol level	J:211773
	decreased heart left ventricle size	J:211773
	decreased plasmacytoid dendritic cell number	J:211773
	enlarged spleen	J:211773
	enlarged thymus	J:211773
	increased circulating lactate dehydrogenase level	J:211773
Tyk2^tm3.1Biat/Tyk2^tm3.1Biat B6NCrl.129P2(C)-Tyk2^tm3.1Biat	increased susceptibility to Picornaviridae infection induced morbidity/mortality	J:187818
	increased susceptibility to Riboviria infection induced morbidity/mortality	J:187818

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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