Rec8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rec8
REC8 meiotic recombination protein
MGI:1929645

26 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rec8^mei8/Rec8^mei8 B6.Cg-Rec8^mei8	abnormal male meiosis	J:205574
Rec8^mei8/Rec8^mei8 involves: 129S4/SvJae * C57BL/6J	abnormal chromosomal synapsis	J:209347
	abnormal male meiosis	J:94208, J:209347
	abnormal synaptonemal complex	J:209347
	absent ovarian follicles	J:94208
	arrest of male meiosis	J:94208, J:209347
	infertility	J:94208
	small ovary	J:94208
	small testis	J:94208
Rec8^tm1.1Kktk/Rec8^tm1.1Kktk involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal female meiosis	J:166151
Rec8^{tm1b(KOMP)Wtsi}/Rec8^{tm1b(KOMP)Wtsi} B6N(Cg)-Rec8^{tm1b(KOMP)Wtsi}	abnormal double-strand DNA break repair	J:280261
	abnormal male meiosis	J:280261
Rec8^{tm1b(KOMP)Wtsi}/Rec8^{tm1b(KOMP)Wtsi} C57BL/6N-Rec8^{tm1b(KOMP)Wtsi}/J	increased circulating aspartate transaminase level	J:211773
	increased circulating cholesterol level	J:211773
	increased circulating HDL cholesterol level	J:211773
	increased mean corpuscular hemoglobin concentration	J:211773
	increased total body fat amount	J:211773
	male infertility	J:211773
Rec8^tm1Mjm/Rec8^tm1Mjm either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * C57BL/6)	abnormal female meiosis	J:99402
	abnormal female reproductive system morphology	J:99402
	abnormal gametogenesis	J:99402
	abnormal ovary morphology	J:99402
	abnormal seminiferous tubule morphology	J:99402
	absent oocytes	J:99402
	absent ovarian follicles	J:99402
	arrest of male meiosis	J:99402
	azoospermia	J:99402
	decreased fetal size	J:99402
	female infertility	J:99402
	male infertility	J:99402
	postnatal growth retardation	J:99402
	prenatal lethality, incomplete penetrance	J:99402

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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