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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tbk1
TANK-binding kinase 1
MGI:1929658
48 phenotypes from 5 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tbk1M1Btlr/Tbk1+
involves: C57BL/6J 		abnormal interferon secretion J:188770
abnormal macrophage physiology J:188770
Tbk1M1Btlr/Tbk1M1Btlr
involves: C57BL/6J 		prenatal lethality, complete penetrance J:188770
Tbk1tm1.1Lex/Tbk1+
involves: 129S4/SvJae * 129S5/SvEvBrd 		abnormal inflammatory response J:166476
decreased basophil cell number J:166476
decreased eosinophil cell number J:166476
Tbk1tm1.1Lex/Tbk1tm1.1Lex
B6.129S5-Tbk1tm1.1Lex 		postnatal lethality, complete penetrance J:166476
Tbk1tm1.1Lex/Tbk1tm1.1Lex
involves: 129S4/SvJae * 129S5/SvEvBrd 		abnormal cytokine level J:166476
abnormal cytokine secretion J:166476
abnormal hair cycle anagen phase J:166476
abnormal inflammatory response J:166476
abnormal skin morphology J:166476
decreased interferon-beta secretion J:166476
decreased NK T cell number J:166476
dermal hyperplasia J:166476
disheveled coat J:166476
hyperkeratosis J:166476
increased circulating interleukin-1 beta level J:166476
increased circulating interleukin-6 level J:166476
increased circulating interleukin-10 level J:166476
increased circulating tumor necrosis factor level J:166476
increased IgA level J:166476
increased interleukin-6 secretion J:166476
increased monocyte cell number J:166476
increased NK T cell number J:166476
increased spleen weight J:166476
increased susceptibility to bacterial infection induced morbidity/mortality J:166476
increased susceptibility to endotoxin shock J:166476
increased tumor necrosis factor secretion J:166476
lymphoid hyperplasia J:166476
prenatal lethality, incomplete penetrance J:166476
skin edema J:166476
skin hyperplasia J:166476
skin inflammation J:166476
sparse hair J:166476
Tbk1tm1Aki/Tbk1tm1Aki
involves: 129P2/OlaHsd * C57BL/6 		lethality throughout fetal growth and development, complete penetrance J:91363
Tbk1tm1Arte/Tbk1tm1Arte
Cd19tm1(cre)Cgn/Cd19+
involves: 129/SvEv * 129P2/OlaHsd * C57BL/6 		abnormal B cell physiology J:188560
abnormal class switch recombination J:188560
abnormal kidney physiology J:188560
increased anti-double stranded DNA antibody level J:188560
increased anti-nuclear antigen antibody level J:188560
increased blood urea nitrogen level J:188560
increased circulating creatinine level J:188560
increased IgA level J:188560
increased IgM level J:188560
increased mature B cell number J:188560
increased urine protein level J:188560
Tbk1tm1Yeh/Tbk1tm1Yeh
involves: 129P2/OlaHsd * C57BL/6J 		lethality throughout fetal growth and development, complete penetrance J:91653
liver degeneration J:91653
liver hemorrhage J:91653
pallor J:91653
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory