Tbk1 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tbk1
TANK-binding kinase 1
MGI:1929658

9 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Tbk1^tm1Aki/Tbk1^tm1Aki Tnf^tm1Sek/Tnf^tm1Sek involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal cytotoxic T cell physiology	J:132662
	decreased cytotoxic T cell cytolysis	J:132662
	decreased IgG1 level	J:132662
	decreased IgG2a level	J:132662
	decreased IgG level	J:132662
	decreased interferon-gamma secretion	J:132662
	normal mortality/aging	J:132662
Tbk1^tm1Arte/Tbk1^tm1Arte Map3k14^tm1Rds/Map3k14^tm1Rds Cd19^tm1(cre)Cgn/Cd19⁺ involves: 129/SvEv * 129P2/OlaHsd * C57BL/6	abnormal B cell differentiation	J:188560
	abnormal immunoglobulin level	J:188560
Tbk1^tm1Yeh/Tbk1^tm1Yeh Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak involves: 129P2/OlaHsd * C57BL/6J	normal mortality/aging	J:91653

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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